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Usage

Uses

Used in Pharmaceutical Industry:
N-(3-bromophenyl)benzenesulfonamide is used as an intermediate in the synthesis of pharmaceuticals for its potential as a carbonic anhydrase inhibitor. This application is significant in the development of drugs targeting conditions related to the dysregulation of carbonic anhydrase enzymes, such as glaucoma, epilepsy, and certain types of cancer.
Used in Dye Industry:
In the dye industry, N-(3-bromophenyl)benzenesulfonamide is utilized as an intermediate in the production of dyes. Its unique chemical structure allows for the creation of dyes with specific color properties and stability, making it valuable in various applications, such as textiles, plastics, and printing inks.
Used in Agrochemical Industry:
N-(3-bromophenyl)benzenesulfonamide is employed as an intermediate in the synthesis of agrochemicals, specifically in the development of pesticides and herbicides. Its biological activity contributes to the effectiveness of these products in controlling pests and unwanted plant growth, thereby supporting agricultural productivity.
Used in Organic Synthesis:
As a chemical reagent, N-(3-bromophenyl)benzenesulfonamide is used in various organic transformations in the field of organic synthesis. Its unique structure allows for a range of chemical reactions, making it a versatile building block for the synthesis of complex organic molecules with potential applications in various industries, including pharmaceuticals, materials science, and specialty chemicals.

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 398151-69-4 3-Bromo-N-ethylaniline 
• 2246860-49-9 C₁₈H₂₂BNO₄S 
• 1377550-63-4 3-amino-N-methyl-6-(3-(phenylsulfonamido)phenyl)pyrazine-2-carboxamide 

Relevant academic research and scientific papers

BENZENE DERIVATIVE

A compound represented by general formula (I) (in the formula, all symbols are as described in the description) or a salt thereof has a potent nerve-protecting and/or -repairing activity, and therefore can be used as a therapeutic agent for neuropathy (e.

Visible-Light-Driven Neutral Nitrogen Radical Mediated Intermolecular Styrene Difunctionalization

A neutral nitrogen radical-mediation strategy, wherein the existing N-H moiety of substrates serves as a neutral nitrogen radical precursor to enable room-temperature intermolecular radical difunctionalization of styrenes under photoredox catalysis, is reported. The reaction shows high functional group tolerance and substrate scope with respect to both components, giving the corresponding products with generally good yields. Preliminary control experiments and DFT calculations are performed to explain the reaction mechanism.

Discovery of a novel series of potent and orally bioavailable phosphoinositide 3-kinase γ inhibitors

The phosphoinositide 3-kinases (PI3Ks) have been linked to an extraordinarily diversified group of cellular functions making these enzymes compelling targets for the treatment of disease. A large body of evidence has linked PI3Kγ to the modulation of autoimmune and inflammatory processes making it an intriguing target for drug discovery. Our high-throughput screening (HTS) campaign revealed two hits that were nominated for further optimization studies. The in vitro activity of the first HTS hit, designated as the sulfonylpiperazine scaffold, was optimized utilizing structure-based design. However, nonoptimal pharmacokinetic properties precluded this series from further studies. An overlay of the X-ray structures of the sulfonylpiperazine scaffold and the second HTS hit within their complexes with PI3Kγ revealed a high degree of overlap. This feature was utilized to design a series of hybrid analogues including advanced leads such as 31 with desirable potency, selectivity, and oral bioavailability.

Microwave-induced rapid access to aromatic and heteroaromatic sulfonamides under solvent-free conditions without using external base

Microwave-induced syntheses of sulfonamides, without using base under solvent-free conditions, have been developed. The process finds its utility because of its simple operational procedure and high yields. Moreover, the process is fast and accommodative to different substituents on aromatic as well as heteroaromatic rings rendering sulfonamides (28 examples).