913948-93-3Relevant articles and documents
Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y12 antagonists for inhibition of platelet aggregation
Caroff, Eva,Meyer, Emmanuel,Treiber, Alexander,Hilpert, Kurt,Riederer, Markus A.
, p. 4323 - 4331 (2014/10/15)
2-Phenyl-pyrimidine-4-carboxamide analogs were identified as P2Y 12 antagonists. Optimization of the carbon-linked or nitrogen-linked substituent at the 6-position of the pyrimidine ring provided compounds with excellent ex vivo potency in the