913952-88-2

Upstream product

• 913952-59-7 6-chloro-2-phenylpyrimidine-4-carboxylic acid 
• 325685-59-4 4-chloro-6-methoxymethyl-2-phenylpyrimidine 
• 339278-89-6 6-methoxymethyl-2-phenylpyrimidin-4-ol 
• 710335-28-7 4-((S)-2-amino-4-tert-butoxycarbonyl-butyryl)piperazine-1-carboxylic acid ethyl ester 
• 1148122-15-9 6-chloro-2-phenylpyrimidine-4-carbonyl chloride 
• 618-39-3 benzamidin 
• 325685-75-4 4-Chloro-6-hydroxymethyl-2-phenylpyrimidine 
• 710335-29-8 ethyl 4-((2S)-2-([(benzyloxy)carbonyl]amino)-5-tert-butoxy-5-oxopentanoyl)piperazine-1-carboxylate 
• 3886-08-6 5-tert-butyl N-benzyloxycarbonyl-L-glutamate 
• 120-43-4 4-ethoxycarbonylpiperazine 

Downstream Products

• 1021702-97-5 4-((S)-4-tert-butoxycarbonyl-2-{[2-phenyl-6-(tetrahydro-pyran-4-yloxy)-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 1021702-73-7 4-[(S)-4-carboxy-2-({6-[2-(2-methoxy-ethoxy)-ethoxy]-2-phenyl-pyrimidine-4-carbonyl} - amino)-butyryl]-piperazine-1-carboxylic acid ethyl ester 
• 913947-47-4 C₃₀H₃₄N₆O₆ 
• 913952-10-0 C₂₅H₃₂N₆O₇ 
• 913952-11-1 C₂₆H₃₂N₆O₈ 
• 913947-39-4 C₂₇H₃₇N₇O₆ 
• 913947-43-0 C₂₉H₃₉N₇O₇ 
• 913947-73-6 4-{(S)-4-carboxy-2-[(2-phenyl-6-piperidin-1-yl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester 
• 913949-21-0 C₂₇H₃₄N₆O₇ 
• 913950-04-6 4-((S)-4-tert-butoxycarbonyl-2-{[6-(3-hydroxy-propyl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 913950-35-3 4-((S)-4-carboxy-2-{[6-(4-methyl-pyrazol-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 913950-12-6 4-((S)-4-tert-butoxycarbonyl-2-{[6-(4-oxo-cyclohexyl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 913950-09-1 4-((S)-4-carboxy-2-{[6-(4-oxo-cyclohexyl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-butyryl)-piperazine-1-carboxylic acid ethyl ester 
• 913951-72-1 4-{(S)-2-[(6-acetyl-2-phenyl-pyrimidine-4-carbonyl)-amino]-4-tert-butoxycarbonyl-butyryl}-piperazine-1-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y12 antagonists for inhibition of platelet aggregation

2-Phenyl-pyrimidine-4-carboxamide analogs were identified as P2Y 12 antagonists. Optimization of the carbon-linked or nitrogen-linked substituent at the 6-position of the pyrimidine ring provided compounds with excellent ex vivo potency in the

2-PHENYL-6-AMINOCARBONYL-PYRIMIDINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR

The invention relates to 2-phenyl-6-aminbcarbonyl-pyrimidinc derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mammals. Formula (1).