913961-18-9

Basic information

• Product Name: 4-(2-tert-butyl-benzenesulfanyl)-nitrobenzene
• Synonyms: 4-(2-tert-butyl-benzenesulfanyl)-nitrobenzene
• CAS NO: 913961-18-9
• Molecular Weight: 287.382
• Mol File: 913961-18-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-tert-butyl-benzenesulfanyl)-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-tert-butyl-benzenesulfanyl)-nitrobenzene(913961-18-9)
• EPA Substance Registry System: 4-(2-tert-butyl-benzenesulfanyl)-nitrobenzene(913961-18-9)

Safety Data

• Hazardous Substances Data: 913961-18-9(Hazardous Substances Data)

Upstream product

• 19728-41-7 2-tert-butylthiophenol 
• 100-00-5 4-chlorobenzonitrile 

Downstream Products

• 913961-14-5 N-[4-(2-tert-butyl-benzenesulfonyl)-phenyl]-5-(2-isopropyl-benzyl)-2,3,4-trimethoxy-benzamide 
• 913961-19-0 4-(2-tert-butyl-benzenesulfonyl)-phenylamine 

Relevant articles and documents

Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

A structure-based approach was employed to design a new class of small-molecule inhibitors of Bcl-2. The most potent compound 5 (TW-37) binds to Bcl-2 with a Ki value of 290 nM and also to Bcl-xL and Mcl-1 with high affinities. Compound 5 potently inhibits cell growth in PC-3 prostate cancer cells with an IC50 value of 200 nM and effectively induces apoptosis in a dose-dependent manner.