914202-84-9

Upstream product

• 500773-98-8 C₁₃H₁₉NO₃ 
• 1276021-72-7 C₁₃H₁₇NO₄ 
• 1100934-14-2 C₁₃H₁₆O₄ 
• 108-95-2 phenol 
• 70080-54-5 4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester 

Downstream Products

• 1276021-66-9 C₁₆H₂₅NO₄ 
• 1276021-70-5 (S)-1-(4-methoxybenzyl)-4-(4-propoxyphenyl)imidazolidin-2-one 
• 1276023-71-2 (S)-5-(4-propoxyphenyl)morpholin-3-one 
• 1276021-73-8 (S)-tert-butyl 2-hydroxy-1-(4-propoxyphenyl)ethylcarbamate 
• 1276021-71-6 C₂₆H₃₀N₄O₃ 
• 1276021-65-8 (S)-1-(1H-benzo[d]imidazole-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one 
• 1276023-70-1 (S)-ethyl 2-(2-(tert-butoxycarbonylamino)-2-(4-propoxyphenyl)ethoxy)acetate 
• 1276023-72-3 C₁₉H₂₃N₃O₃ 

Relevant academic research and scientific papers

NOVEL INHIBITORS

The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water.