914334-87-5Relevant academic research and scientific papers
Synthesis and characterization of well-defined lactic acid-PEG cooligomers and its tricarbonyl rhenium conjugates
Zhu, Hua,Xu, Xiaoping,Cui, Wei,Zhang, Yuanqing,Mo, Huaping,Shen, Yu-Mei
, p. 1745 - 1752 (2012/02/16)
This article describes the synthesis and characterization of hydroxyl tailored, molecularly defined biodegradable cooligomers capable of chelating rhenium for potential radiopharmaceuticals. New insights were gained during the synthesis of lactide based on dimethylaminopyridine-catalyzed transesterification.
Host-directed inhibitors of myxoviruses: Synthesis and in vitro biochemical evaluation
Sun, Aiming,Ndungu, J. Maina,Krumm, Stefanie A.,Yoon, Jeong-Joong,Thepchatri, Pahk,Natchus, Michael,Plemper, Richard K.,Snyder, James P.
scheme or table, p. 798 - 803 (2011/12/16)
Drugs targeted to viral proteins are highly vulnerable to the development of viral resistance. One little explored approach to the treatment of viral diseases is the development of agents that target host factors required for virus replication. Myxoviruses are predominantly associated with acute disease and, thus, ideally suited for this approach since the necessary treatment time is anticipated to be limited. High-throughput screening previously identified benzimidazole 22407448 with broad antiviral activity against different influenza virus and paramyxovirus strains. Hit to lead chemistry has generated 6p (JMN3-003) with potent antiviral activity against a panel of myxovirus family members exhibiting EC50 values in the low nanomolar range.
