909025-03-2Relevant academic research and scientific papers
Hydrophilic Oligo(lactic acid)s Captured by a Hydrophobic Polyaromatic Cavity in Water
Kusaba, Shunsuke,Yamashina, Masahiro,Akita, Munetaka,Kikuchi, Takashi,Yoshizawa, Michito
, p. 3706 - 3710 (2018/03/05)
Biologically relevant hydrophilic molecules rarely interact with hydrophobic compounds and surfaces in water owing to effective hydration. Nevertheless, herein we report that the hydrophobic cavity of a polyaromatic capsule, formed through coordination-driven self-assembly, can encapsulate hydrophilic oligo(lactic acid)s in water with relatively high binding constants (up to Ka=3×105 m?1). X-ray crystallographic and ITC analyses revealed that the unusual host–guest behavior is caused by enthalpic stabilization through multiple CH–π and hydrogen-bonding interactions. The polyaromatic cavity stabilizes hydrolyzable cyclic di(lactic acid) and captures tetra(lactic acid) preferentially from a mixture of oligo(lactic acid)s even in water.
Amplifying (Im)perfection: The Impact of Crystallinity in Discrete and Disperse Block Co-oligomers
Van Genabeek, Bas,Lamers, Brigitte A. G.,De Waal, Bas F. M.,Van Son, Martin H. C.,Palmans, Anja R. A.,Meijer
, p. 14869 - 14872 (2017/10/31)
Crystallinity is seldomly utilized as part of the microphase segregation process in ultralow-molecular-weight block copolymers. Here, we show the preparation of two types of discrete, semicrystalline block co-oligomers, comprising an amorphous oligodimethylsiloxane block and a crystalline oligo-l-lactic acid or oligomethylene block. The self-assembly of these discrete materials results in lamellar structures with unforeseen uniformity in the domain spacing. A systematic introduction of dispersity reveals the extreme sensitivity of the microphase segregation process toward chain length dispersity in the crystalline block.
Unique cation binding capability of cyclic oligo(l-lactic acid) (l-COLA)
Kogame, Chizuru,Kida, Toshiyuki,Fujiwara, Tomoko,Akashi, Mitsuru
, p. 1675 - 1678 (2015/03/14)
Cyclic l-lactic acid octamer (l-COLA-8) shows a unique complexing capability towards alkali and alkali earth metal cations in acetonitrile-d3/chloroform-d (9/1). The valence of the cation affects the stoichiometry of the complexes between l-COLA-8 and the cation; l-COLA-8 forms a 2:1 complex with alkali metal cations, but forms a 1:1 complex with alkali earth metal cations. Additionally, l-COLA-8 shows a binding selectivity for Rb+ and Ba2+, which have a diameter about 3 ?.
Synthesis and characterization of well-defined lactic acid-PEG cooligomers and its tricarbonyl rhenium conjugates
Zhu, Hua,Xu, Xiaoping,Cui, Wei,Zhang, Yuanqing,Mo, Huaping,Shen, Yu-Mei
, p. 1745 - 1752 (2012/02/16)
This article describes the synthesis and characterization of hydroxyl tailored, molecularly defined biodegradable cooligomers capable of chelating rhenium for potential radiopharmaceuticals. New insights were gained during the synthesis of lactide based on dimethylaminopyridine-catalyzed transesterification.
