914366-93-1

Upstream product

• 1008781-49-4 C₁₃H₁₈O₃ 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 503620-04-0 (2S,3S)-5-(benzyloxy)-2-methylpentane-1,3-diol 
• 1464823-37-7 (2R,3S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-5-(benzyloxy)-3-hydroxy-2-methylpentan-1-one 
• 19790-60-4 3-Benzyloxypropanal 
• 95532-05-1 (E)-5-Benzyloxy-2-methyl-pent-2-enal 
• 914366-68-0 (E,4S,5S)-ethyl 7-benzyloxy-4,5-dihydroxy-4-methylhept-2-enoate 
• 869898-80-6 (2E,4E)-ethyl 7-benzyloxy-4-methylhepta-2,4-dienoate 
• 75-24-1 trimethylaluminum 
• 959125-19-0 (E)-ethyl 3-((2R,3S)-3-(2-(benzyloxy)ethyl)oxiran-2-yl)acrylate 
• 914366-86-2 (E)-ethyl 3-((4S,5S)-5-(2-(benzyloxy)ethyl)-4-methyl-2-oxo-1,3-dioxolan-4-yl)acrylate 

Downstream Products

• 1464823-43-5 (2S,3S,6S)-6-allyl-2-(2-(benzyloxy)ethyl)-3-methyltetrahydro-2H-pyran 
• 863492-78-8 (2S,3S,6R)-6-allyl-2-(2-(benzyloxy)ethyl)-3-methyltetrahydro-2H-pyran 
• 1464823-10-6 (5S,6S)-6-(2-(benzyloxy)ethyl)-5-methyltetrahydro-2H-pyran-2-ol 
• 1464823-38-8 (4S,5S)-ethyl 7-(benzyloxy)-5-hydroxy-4-methylheptanoate 
• 1252009-20-3 (4S,5S,E)-ethyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-4-methylhept-2-enoate 

Relevant academic research and scientific papers

Novel iodine catalyzed diastereoselective synthesis of trans-2,6- disubstituted tetrahydro-2H-pyrans: Synthesis of C1-C13 fragment of bistramide-A

A new method for the stereoselective synthesis of trans 2.6-disubstituted tetrahydro-2H-pyrans has been developed involving iodine catalyzed allylation of tetrahydro-2H-pyranol with excellent trans selectivity. The method was also applied toward the construction of C1-C13 fragment of bistramide-A in 11 steps with 21.4% overall yield.

Synthetic studies on cytotoxic macrolides cruentarens A and B: Stereoselective synthesis of the C8C19 segment of cruentarens A and B

A stereoselective synthesis of the C8C19 segment of cruentarens A and B, cytotoxic natural products, has been accomplished. The key steps involve a stereoselective radical cyclization, stereospecific methylation of a c, d-epoxy acrylate, nucleophilic epoxide ring opening and a cis-Wittig olefination.

Stereoselective total synthesis of bistramide A

(Chemical Equation Presented) A highly stereoselective and convergent total synthesis of bistramide A is described. The salient feature of this synthesis is the construction of the spiroketal subunit by hydrolysis of dialkylated tosylmethyl isocyanide derivative derived via alkylation of TosMIC with suitably substituted halohydrin derivatives.

De novo synthesis of 2-substituted syn-1,3-diols via an iterative asymmetric hydration strategy

(Chemical Equation Presented) The enantioselective syntheses of several protected 4-substituted syn-3,5-dihydroxy carboxylic esters have been achieved from the corresponding achiral (E,E)- or (E,Z)-1,3-dienoates. The route relies upon an enantio- and regi