91441-23-5Relevant academic research and scientific papers
Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride
Beylin,Colbry,Goel,Haky,Johnson,Johnson,Kanter,Leeds,Leja,Lewis,Rithner,Showalter,Sercel,Turner,Uhlendorf
, p. 85 - 96 (2007/10/02)
Improved processes for the synthesis of bulk quantities of the anthrapyrazole clinical agents CI-937, CI-941, and piroxantrone hydrochloride are reported. Reported also are detailed analytical and spectroscopic data for these agents and intermediates of t
Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias
Showalter,Johnson,Hoftiezer,Turner,Werbel,Leopold,Shillis,Jackson,Elslager
, p. 121 - 131 (2007/10/02)
Chromophore modification of the anthracenediones related to mitoxantrone in an attempt to provide agents with diminished or no cardiotoxicity has resulted in a novel class of DNA binders, the anthrapyrazoles. Their synthesis was carried out by a two-stage
Process for preparing substituted anthra[1,9-cd]pyrazol-6(2H)-ones
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, (2008/06/13)
An improved process for making anthra[1,9-cd]pyrazol-6(2H)-ones from 1,4-dichloro-5,8-disubstituted-9,10-anthracenediones and a hydrazine is disclosed. The compounds produced have antibacterial, antifungal, antileukaemic, and antitumor activity.
Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones
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, (2008/06/13)
Substituted anthra[1,9-cd]pyrazol-6(2H-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed.
