914458-20-1 Usage
Uses
Used in Pharmaceutical Industry:
(1-Hexyl-5-phenyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone is used as a high affinity ligand for the cannabinoid CB1 and CB2 receptors. Its interaction with these receptors is crucial for the development of potential therapeutic agents that can modulate the endocannabinoid system, which plays a significant role in various physiological processes, including pain, mood, and appetite regulation. This application is particularly relevant for the treatment of conditions such as chronic pain, anxiety, and obesity.
Used in Drug Development:
As a high affinity ligand for cannabinoid receptors, (1-Hexyl-5-phenyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone serves as a valuable starting point for the design and synthesis of novel drugs targeting the endocannabinoid system. Researchers can use this compound to develop new medications with improved efficacy, selectivity, and reduced side effects compared to existing treatments.
Used in Research Applications:
(1-Hexyl-5-phenyl-1H-pyrrol-3-yl)(naphthalen-1-yl)methanone is also utilized in scientific research to study the structure, function, and pharmacology of the cannabinoid receptors. Its high affinity for these receptors makes it an ideal tool for investigating the molecular mechanisms underlying the endocannabinoid system's role in various physiological and pathological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 914458-20-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,4,4,5 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 914458-20:
(8*9)+(7*1)+(6*4)+(5*4)+(4*5)+(3*8)+(2*2)+(1*0)=171
171 % 10 = 1
So 914458-20-1 is a valid CAS Registry Number.
914458-20-1Relevant articles and documents
1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors
Huffman, John W.,Padgett, Lea W.,Isherwood, Matthew L.,Wiley, Jenny L.,Martin, Billy R.
, p. 5432 - 5435 (2007/10/03)
Two series of 1-alkyl-2-aryl-4-(1-naphthoyl)pyrroles were synthesized and their affinities for the cannabinoid CB1 and CB2 receptors were determined. In the 2-phenyl series (5) the N-alkyl group was varied from n-propyl to n-heptyl. A second series of 23 1-pentyl-2-aryl-4-(1-naphthoyl)-pyrroles (6) was also prepared. Several compounds in both series have CB1 receptor affinities in the 6-30 nM range. The high affinities of these pyrrole derivatives relative to JWH-030 (1, R = C5H11) support the hypothesis that these pyrroles interact with the CB1 receptor primarily by aromatic stacking.
