914458-48-3

Basic information

• Product Name: naphthalen-1-yl(5-phenyl-1H-pyrrol-3-yl)methanone
• CAS NO: 914458-48-3
• Molecular Weight: 297.356
• Mol File: 914458-48-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: naphthalen-1-yl(5-phenyl-1H-pyrrol-3-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: naphthalen-1-yl(5-phenyl-1H-pyrrol-3-yl)methanone(914458-48-3)
• EPA Substance Registry System: naphthalen-1-yl(5-phenyl-1H-pyrrol-3-yl)methanone(914458-48-3)

Safety Data

• Hazardous Substances Data: 914458-48-3(Hazardous Substances Data)

Upstream product

• 103-81-1 Benzeneacetamide 
• 941-98-0 1'-naphthacetophenone 
• 153633-36-4 2-phenyl-1-(p-toluenesulfonyl)pyrrole 
• 613-91-2 acetophenone oxime 
• 3042-22-6 2-phenyl-1H-pyrrole 
• 914458-46-1 2-phenyl-4-(1-naphthoyl)-N-p-toluenesulfonylpyrrole 

Downstream Products

• 914458-20-1 (1-hexyl-5-phenyl-1H-pyrrol-3-yl)-1-naphthalenylmethanone 
• 914458-21-2 (1-heptyl-5-phenyl-1H-pyrrol-3-yl)-1-naphthalenylmethanone 

Relevant articles and documents

[3+2] Anionic Cycloaddition of Isocyanides to Acyclic Enamines and Enaminones: A New, Simple, and Convenient Method for the Synthesis of 2,4-Disubstituted Pyrroles

We herein demonstrate a new approach for the synthesis of 2,4-disubstituted pyrroles by [3+2] cycloaddition reaction of isocyanides to the activated double bond of various enamines and enaminones. This process paved the way for the synthesis a series of 2,4-disubstituted pyrroles, which are known to be intermediates in the synthesis of biologically active compounds, in good to excellent yields from simple and commercially available starting materials. The process is carried out efficiently using a strong base, tBuOK, at low temperatures (0 °C). The described method is simple, proceeds in one step, does not require additional catalysts and hence, has a wide scope.