914639-63-7

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 350-46-9 4-Fluoronitrobenzene 
• 3417-91-2 L-tyrosine methyl ester HCl 
• 60-18-4 L-tyrosine 
• 914639-64-8 (2S)-2-[(t-butoxycarbonyl)amino]-3-[4-(4-nitrophenoxy)phenyl]propanoic acid methyl ester 

Downstream Products

• 914639-64-8 (2S)-2-[(t-butoxycarbonyl)amino]-3-[4-(4-nitrophenoxy)phenyl]propanoic acid methyl ester 

Relevant academic research and scientific papers

Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains

As an important member of anti-apoptotic Bcl-2 protein, myeloid cell leukemia sequence 1 (Mcl-1) protein is an attractive target for cancer therapy. In this study, a new series of pyrrolidine derivatives as Mcl-1 inhibitors were developed by mainly modifying the amino acid side chain of compound 1. Among them, compound 18 (Ki= 0.077 μM) exhibited better potent inhibitory activities towards Mcl-1 protein compared to positive control Gossypol (Ki= 0.18 μM). In addition, compound 40 possessed good antiproliferative activities against PC-3 cells (Ki= 8.45 μM), which was the same as positive control Gossypol (Ki= 7.54 μM).

DIPEPTIDYL PEPTIDASE IV INHIBITORS

Abstract The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, their hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabo

NOVEL HETEROCYCLIC DERIVATIVES

The present invention relates to novel heterocyclic derivatives of the general formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions. The present invention more particularly provides novel compounds of the general for