914933-63-4

Upstream product

• 56518-42-4 4-bromo-3,5-dimethoxybenzoic acid 

Downstream Products

• 914933-64-5 1-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-dimethoxy-phenyl]-2-(2-methyl-[1,3]dioxolan-2-yl)-ethanol 
• 1356493-16-7 C₂₀H₃₂O₄Si 
• 1246370-19-3 C₂₀H₃₆O₄Si 
• 914933-66-7 2-{2-[3-bromo-4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-dimethoxy-phenyl]-2-triisopropylsilanyloxy-ethyl}-2-methyl-[1,3]dioxolane 
• 914933-65-6 2-{2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-dimethoxy-phenyl]-2-triisopropylsilanyloxy-ethyl}-2-methyl-[1,3]dioxolane 
• 914933-67-8 {2-bromo-3,5-dimethoxy-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-1-triisopropylsilanyloxy-ethyl]-phenyl}-methanol 
• 914933-62-3 2-bromo-3,5-dimethoxy-4-[2-(2-methyl-[1,3]dioxolan-2-yl)-1-triisopropylsilanyloxy-ethyl]-benzaldehyde 

Relevant academic research and scientific papers

Total synthesis of topopyrones B and D

(Chemical Equation Presented) We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.

Yicathins B and C and Analogues: Total Synthesis, Lipophilicity and Biological Activities

Natural products have always been an important source of new hits and leads in drug discovery, with the marine environment being regarded as a significant source of novel and exquisite bioactive compounds. Yicathins B and C are two marine-derived xanthones that have shown antibacterial and antifungal activity. Herein, the total synthesis of these yicathins and six novel analogues is reported for the first time. As marine natural products tend to have very lipophilic scaffolds, the lipophilicity of yicathins and their analogues was evaluated in the classical octanol/water system and a biomimetic model-based system. As the xanthonic nucleus is a “privileged structure”, other biological activities were evaluated, namely antitumor and anti-inflammatory activities. An interesting anti-inflammatory activity was identified for yicathin analogues that paves the way for the design of dual activity (anti-infective and anti-inflammatory) marine-inspired xanthone derivatives.

Concise total synthesis of permethylated anigopreissin a, a new benzofuryl resveratrol dimer

The versatile preparation of permethylated anigopreissin A (1) has been accomplished from methyl 3,5-dihydroxybenzoate. The key steps of the synthesis are sequential Sonogashira and Suzuki cross-couplings for the construction of the 2,3-diarylbenzo[b]furan moiety and Wittig olefination for the introduction of the styryl group.