915036-72-5

Upstream product

• 915037-64-8 3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-amine 
• 915037-63-7 N,N-dimethyl-4-(5-nitro-1H-indol-3-yl)cyclohex-3-enamine 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 168897-51-6 methyl thiophene-2-carboximidothioate 
• 915037-54-6 4-(5-nitro-1H-indol-3-yl)cyclohex-3-enone 
• 915037-53-5 5-nitro-3-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1H-indole 
• 6146-52-7 5-nitroindole 

Downstream Products

• 1152478-29-9 (S)-N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide 
• 1152478-31-3 (R)-N-(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indol-5-yl)thiophene-2-carboximidamide 

Relevant academic research and scientific papers

First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain

A family of different 3,5-disubstituted indole derivatives having 6-membered rings were designed, synthesized, and demonstrated inhibition of human nitric oxide synthase (NOS) with norepinephrine reuptake inhibitory activity (NERI). The structure-activity

3,5 - SUBSTITUTED INDOLE COMPOUNDS HAVING NOS AND NOREPINEPHRINE REUPTAKE INHIBITORY ACTIVITY

The present invention relates to novel 3,5-substituted indole compounds of Formula (I) having nitric oxide synthase (NOS) inhibitory activity together with inhibitory activity at the norepinephrine transporter (NET), to pharmaceutical and diagnostic compositions containing them, and to their medical use.

Substituted indole compounds having NOS inhibitory activity

The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination w