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915087-16-0

4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide, also known as Defluoro-MDV 3100 (Defluoro-enzalutamide), is an impurity of Enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor, preventing nuclear translocation and co-activator recruitment of the ligand-receptor complex. 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide has been shown to induce tumor cell apoptosis and is used for the treatment of castration-resistant prostate cancer.

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  • 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl}-N-methylbenzamide

    Cas No: 915087-16-0

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  • Newblue 915087-16-0 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide

    Cas No: 915087-16-0

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  • 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide

    Cas No: 915087-16-0

  • USD $ 10.0-10.0 / Milligram

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  • 915087-16-0 Structure

  • Basic information

    1. Product Name: 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide
    2. Synonyms: 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide
    3. CAS NO:915087-16-0
    4. Molecular Formula: C21H17F3N4O2S
    5. Molecular Weight: 446.4454896
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 915087-16-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide(915087-16-0)
    11. EPA Substance Registry System: 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide(915087-16-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 915087-16-0(Hazardous Substances Data)

915087-16-0 Usage

Uses

Used in Pharmaceutical Industry:
4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide is used as an impurity in the production of Enzalutamide, an androgen-receptor antagonist for the treatment of castration-resistant prostate cancer. Its presence in the compound may affect the efficacy and safety of the drug, making it important to monitor and control its levels during the manufacturing process.

Check Digit Verification of cas no

The CAS Registry Mumber 915087-16-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,0,8 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 915087-16:
(8*9)+(7*1)+(6*5)+(5*0)+(4*8)+(3*7)+(2*1)+(1*6)=170
170 % 10 = 0
So 915087-16-0 is a valid CAS Registry Number.

915087-16-0Upstream product

915087-16-0Downstream Products

915087-16-0Relevant articles and documents

Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC)

Jung, Michael E.,Ouk, Samedy,Yoo, Dongwon,Sawyers, Charles L.,Chen, Charlie,Tran, Chris,Wongvipat, John

experimental part, p. 2779 - 2796 (2010/09/05)

A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.

DIARYLHYDANTOIN COMPOUNDS

-

Page/Page column 68, (2008/06/13)

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for syntheszing them and using them in the treatment of hormone refractory prostate cancer.

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