915093-17-3

Upstream product

• 915093-14-0 2-chloro-2,2-difluoro-N-(p-methoxyphenyl)acetamide 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 330801-31-5 2,2-difluoro-3-hydroxy-N-(p-methoxyphenyl)-4-methylpentanamide 
• 330801-33-7 3,3-difluoro-4-isopropyl-N-(p-methoxyphenyl)azetidin-2-one 

Relevant academic research and scientific papers

Ethyl difluoro(trimethylsilyl)acetate and difluoro(trimethylsilyl) acetamides - Precursors of 3,3-difluoroazetidinones

Difluoro(trimethylsilyl)acetamides 7 have been prepared from chlorodifluoroacetamides 5 by electrochemical silylation. When condensed with carbonyl compounds, they were shown to be precursors of 2,2-difluoro-3- hydroxyacetamides 8. N-(p-Methoxyphenyl)-2,2-difluoro-3-hydroxy-4- methylvaleramide (8a) has been converted into the correspending 3,3-difluoroazetidinone 9a. This new route to 3,3-difluoroazetidinones is shown to be an alternative to the one utilizing the condensation of ethyl difluoro(trimethylsilyl)acetate with imines. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.