330801-31-5Relevant academic research and scientific papers
Ethyl difluoro(trimethylsilyl)acetate and difluoro(trimethylsilyl) acetamides - Precursors of 3,3-difluoroazetidinones
Bordeau, Michel,Frebault, Frederic,Gobet, Mallory,Picard, Jean-Paul
, p. 4147 - 4154 (2007/10/03)
Difluoro(trimethylsilyl)acetamides 7 have been prepared from chlorodifluoroacetamides 5 by electrochemical silylation. When condensed with carbonyl compounds, they were shown to be precursors of 2,2-difluoro-3- hydroxyacetamides 8. N-(p-Methoxyphenyl)-2,2-difluoro-3-hydroxy-4- methylvaleramide (8a) has been converted into the correspending 3,3-difluoroazetidinone 9a. This new route to 3,3-difluoroazetidinones is shown to be an alternative to the one utilizing the condensation of ethyl difluoro(trimethylsilyl)acetate with imines. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ,γ-difluoro-α,β-enoates
Otaka, Akira,Watanabe, Hideaki,Mitsuyama, Etsuko,Yukimasa, Akira,Tamamura, Hirokazu,Fujii, Nobutaka
, p. 285 - 287 (2007/10/03)
γ,γ-Difluoro-α,β-enoates are reduced with organocopper reagents to afford the corresponding γ-fluoro-β,γ-enoates. This organocopper-mediated reduction was applied to the synthesis of (Z)-fluoroalkene dipeptide isosteres.
