915124-86-6

Basic information

• Product Name: TelMisartan AMide
• Synonyms: TelMisartan AMide;4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-1H-benziMidazol]-1'-yl)Methyl][1,1'-biphenyl]-2-carboxaMide;TelMisartan IMpurity F;TelMisartan EP IMpurity F;[1,1'-Biphenyl]-2-carboxaMide, 4'-[(1,4'-diMethyl-2'-propyl[2,6'-bi-1H-benziMidazol]-1'-yl) Methyl]-;2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl] methyl}phenyl)benzamide
• CAS NO: 915124-86-6
• Molecular Formula: C₃₃H₃₁N₅O
• Molecular Weight: 513.63214
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 915124-86-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: TelMisartan AMide(CAS DataBase Reference)
• NIST Chemistry Reference: TelMisartan AMide(915124-86-6)
• EPA Substance Registry System: TelMisartan AMide(915124-86-6)

Safety Data

• Hazardous Substances Data: 915124-86-6(Hazardous Substances Data)

Usage

Uses

An amide impurity of Temisartan (D294250).

Upstream product

• 144701-48-4 telmisatran 
• 144702-27-2 4'-[[2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl 

Downstream Products

• 144701-48-4 telmisatran 

Relevant articles and documents

Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells

4’-((2-Propyl-1H-benzo[d]imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carboxylic acid derived from telmisartan was identified as lead for the design of cell death modulators. In this study, we evaluated the efficacy of telmisartan itself and other sartans in combination with imatinib against K562-resistant cells. The findings were directly used to further optimize the lead structure. Telmisartan and candesartan cilexetil represented the most effective sartans, thus the influence of carboxyl/methyl carboxylate groups at positions 7 (compounds 6, 7) or 4 (compounds 12–14) at the benzimidazole core was studied. Additionally, according to the results of a former structure-activity study, telmisartan was transformed to the related amide (1). Telmisartan amide 1, as well as the esters 6 and 12 markedly sensitized the resistant CML cells to imatinib treatment. Correlation with their potency to activate PPARγ is not given. Candesartan cilexetil, telmisartan and 1 showed the profile of partial agonists at PPARγ with EC50 values of 4.2, 4.3 and 9.1 μM, respectively, while 6 and 12 caused only marginal intrinsic activation at 10 μM (Amax = 22% and 13%). However, the repression of the STAT5 phosphorylation relates with the possibility to sensitize K562-resistant CML cells to imatinib treatment. It is worth mentioning that all compounds were per se non-cytotoxic at relevant concentrations.