915725-75-6

Upstream product

• 643-79-8 o-phthalic dicarboxaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 591-51-5 phenyllithium 
• 100-52-7 benzaldehyde 
• 915725-70-1 (2S,4aS,7R,8aR)-3-benzyl-2-(2-bromophenyl)-4,4,7-trimethyl-octahydro-2H-benzo[e][1,3]oxazine 
• 865262-74-4 2-((2S,3S,4aS,7R,8aR)-3-Benzyl-4,4,7-trimethyl-octahydro-benzo[e][1,3]oxazin-2-yl)-benzaldehyde 
• 915725-67-6 (1R,2'S,4a'S,7'R,8a'R)-1-(2-(N-benzyl-4',4',7'-trimethyl-octahydro-2H-benzo[e][1,3]oxazin-2'-yl)phenyl)phenyl-methanol 

Downstream Products

• 5398-11-8 3‐phenylisobenzofuran‐1(3H)‐one 

Relevant academic research and scientific papers

A direct efficient diastereoselective synthesis of enantiopure 3-substituted-isobenzofuranones

Condensation of (-)-8-benzylaminomenthol with o-phthaldehyde lead to the chiral perhydro-1,3-benzoxazine 2 as single diastereoisomer. That compound reacted with different organometallics leading to 3 in excellent de. Hydrolysis of carbinols, followed by oxidation of the intermediates allowed for the synthesis of enantiopure phthalides.