915731-88-3

Usage

Uses

Used in Pharmaceutical Industry:
[4-(2,4-Dichlorophenyl)-6-dimethylcarbamoylmethyl-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylmethyl]carbamic acid tert-butyl ester is used as a potential pharmaceutical compound for its possible biological activities and therapeutic effects. Its complex structure and various functional groups may contribute to its efficacy in treating specific diseases or conditions.
Used in Organic Synthesis:
[4-(2,4-Dichlorophenyl)-6-dimethylcarbamoylmethyl-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylmethyl]carbamic acid tert-butyl ester is used as a building block in organic synthesis for the development of new drugs or pharmaceutical compounds. Its unique structure and functional groups can be utilized to create novel molecules with desired properties and applications.
Used in Medicinal Chemistry:
[4-(2,4-Dichlorophenyl)-6-dimethylcarbamoylmethyl-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-3-ylmethyl]carbamic acid tert-butyl ester is used as a starting material in medicinal chemistry to explore its potential as a lead compound for drug discovery. Its complex structure and functional groups can be modified to optimize its pharmacological properties and improve its therapeutic potential.

InChI:InChI=1/C24H28Cl2N4O4/c1-13-16(10-27-23(33)34-24(2,3)4)20(15-8-7-14(25)9-17(15)26)21-18(28-13)11-30(22(21)32)12-19(31)29(5)6/h7-9H,10-12H2,1-6H3,(H,27,33)

Upstream product

• 124-40-3 dimethyl amine 
• 915731-62-3 (R)-tert-Butyl 2-(3-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate 
• 915296-81-0 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 915296-80-9 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 915297-06-2 tert-butyl 2-(4-(2,4-dichlorophenyl)-3-(hydroxymethyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate 
• 915297-05-1 6-(2-tert-butoxy-2-oxoethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid 
• 915297-04-0 benzyl 6-(2-tert-butoxy-2-oxoethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate 
• 915296-79-6 (Z)-ethyl 4-chloro-2-(2,4-dichlorobenzylidene)-3-oxobutanoate 
• 1454705-52-2 tert-butyl 2-(3-(chlorocarbonyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant academic research and scientific papers

Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b] pyridin-6(7H)-yl)-N, N-dimethylacetamide (BMS-767778)

Optimization of a 5-oxopyrrolopyridine series based upon structure-activity relationships (SARs) developed from our previous efforts on a number of related bicyclic series yielded compound 2s (BMS-767778) with an overall activity, selectivity, efficacy, PK, and developability profile suitable for progression into the clinic. SAR in the series and characterization of 2s are described.

Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods

Compounds are provided having the formula (I) wherein R, X, Y, Z, A and n are as defined herein, which are inhibitors of dipeptidyl peptidase IV and thus are useful in treating diabetes and related diseases.