915761-35-2

Basic information

• Product Name: 4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid
• CAS NO: 915761-35-2
• Molecular Weight: 548.561
• Mol File: 915761-35-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid(915761-35-2)
• EPA Substance Registry System: 4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid(915761-35-2)

Safety Data

• Hazardous Substances Data: 915761-35-2(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 915759-45-4 5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide 

Relevant articles and documents

Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II

Piperidinyl diphenylsulfonyl sulfonamides are a novel class of molecules that have inhibitory binding affinity for sFRP-1. As a secreted protein sFRP-1 inhibits the function of the secreted Wnt glycoprotein. Therefore, as inhibitors of sFRP-1 these small molecules facilitate the Wnt/β-catenin canonical signaling pathway. Details of the structure-activity relationships and biological activity of this structural class of compounds will be discussed.