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915759-45-4

915759-45-4

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915759-45-4 Usage

Description

WAY-316606 is an inhibitor of secreted frizzled-related protein 1 (sFRP-1; IC50 = 0.5 μM). It increases Wnt signaling in U2OS osteosarcoma cells (EC50 = 0.65 μM). WAY-316606 increases total bone area in a murine calvarial organ culture assay when used at concentrations greater than 0.1 nM.

Check Digit Verification of cas no

The CAS Registry Mumber 915759-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,7,5 and 9 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 915759-45:
(8*9)+(7*1)+(6*5)+(5*7)+(4*5)+(3*9)+(2*4)+(1*5)=204
204 % 10 = 4
So 915759-45-4 is a valid CAS Registry Number.

915759-45-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(benzenesulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide

1.2 Other means of identification

Product number -
Other names CS-0996

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:915759-45-4 SDS

915759-45-4Synthetic route

2-methyl-1,2-epoxypropane
558-30-5

2-methyl-1,2-epoxypropane

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

N-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide
915759-79-4

N-[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
In ethanol Reflux;70%
bromo-acetic acid amide
683-57-8

bromo-acetic acid amide

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

2-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl)amino)piperidin-1-yl]acetamide
915761-37-4

2-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl)amino)piperidin-1-yl]acetamide

Conditions
ConditionsYield
With triethylamine53%
succinic acid anhydride
108-30-5

succinic acid anhydride

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid
915761-35-2

4-oxo-4-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]butanoic acid

Conditions
ConditionsYield
In ethanol at 150℃; for 0.166667h; Microwave irradiation;33%
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

2-bromoethanol
540-51-2

2-bromoethanol

N-[1-(2-hydroxyethyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide
915760-45-1

N-[1-(2-hydroxyethyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 150℃; for 0.166667h; Microwave irradiation;30%
(4-(tert-butoxycarbonyl)phenyl)boronic acid
850568-54-6

(4-(tert-butoxycarbonyl)phenyl)boronic acid

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C29H31F3N2O6S2

C29H31F3N2O6S2

Conditions
ConditionsYield
With copper diacetate; triethylamine
glutaric anhydride,
108-55-4

glutaric anhydride,

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

5-oxo-5-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]pentanoic acid
915761-50-1

5-oxo-5-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl)amino)piperidin-1-yl]pentanoic acid

Conditions
ConditionsYield
In ethanol at 150℃; Microwave irradiation;
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C7H5ClN4O2S
476362-71-7

C7H5ClN4O2S

5-(phenylsulfonyl)-N-(1-([3-(2H-tetrazol-5-yl)phenyl]-sulfonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915762-51-5

5-(phenylsulfonyl)-N-(1-([3-(2H-tetrazol-5-yl)phenyl]-sulfonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
3-(tert-butoxycarbonyl)phenylboronic acid
220210-56-0

3-(tert-butoxycarbonyl)phenylboronic acid

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C29H31F3N2O6S2

C29H31F3N2O6S2

Conditions
ConditionsYield
With copper diacetate; triethylamine
bromoacetic acid tert-butyl ester
5292-43-3

bromoacetic acid tert-butyl ester

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C24H29F3N2O6S2

C24H29F3N2O6S2

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 120℃; for 0.166667h; Microwave irradiation;
tert-butyl 3-bromopropionate
55666-43-8

tert-butyl 3-bromopropionate

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

C25H31F3N2O6S2

C25H31F3N2O6S2

Conditions
ConditionsYield
With triethylamine
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

p-carboxyphenylsulfonyl chloride
10130-89-9

p-carboxyphenylsulfonyl chloride

4-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]sulfonyl)benzoic acid
915761-11-4

4-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]sulfonyl)benzoic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

3-Carboxybenzenesulfonyl chloride
4025-64-3

3-Carboxybenzenesulfonyl chloride

3-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]sulfonyl)benzoic acid
915761-10-3

3-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]sulfonyl)benzoic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

3-cyanobenzene sulfonyl chloride
56542-67-7

3-cyanobenzene sulfonyl chloride

N-(1-[(3-cyanophenyl)sulfonyl]piperidin-4-yl)-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide
915762-41-3

N-(1-[(3-cyanophenyl)sulfonyl]piperidin-4-yl)-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid
84358-13-4

N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

tert-butyl 4-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]carbonyl)piperidine-1-carboxylate
915761-71-6

tert-butyl 4-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]carbonyl)piperidine-1-carboxylate

Conditions
ConditionsYield
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

5-(phenylsulfonyl)-N-[1-(phenylsulfonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide
915760-82-6

5-(phenylsulfonyl)-N-[1-(phenylsulfonyl)piperidin-4-yl]-2-(trifluoromethyl)benzenesulfonamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃;
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid
157688-46-5

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

tert-butyl 4-(2-oxo-2-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]ethyl)piperidine-1-carboxylate
915762-21-9

tert-butyl 4-(2-oxo-2-[4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]ethyl)piperidine-1-carboxylate

Conditions
ConditionsYield
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

(R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid
72925-16-7

(R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

tert-butyl (3R)-3-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]carbonyl)pyrrolidine-1-carboxylate
915763-12-1

tert-butyl (3R)-3-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]carbonyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide
915759-45-4

5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide

(S)-1-N-boc-β-proline
140148-70-5

(S)-1-N-boc-β-proline

tert-butyl (3S)-3-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]carbonyl)pyrrolidine-1-carboxylate
915763-13-2

tert-butyl (3S)-3-([4-(([5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl)amino)piperidin-1-yl]carbonyl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield

915759-45-4Upstream product

915759-45-4Downstream Products

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