91613-11-5Relevant articles and documents
Preparing method for tauro ursodesoxy cholic acid
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Paragraph 0040; 0041; 0042, (2016/10/09)
The invention discloses a preparing method for tauro ursodesoxy cholic acid. The method comprises the following steps that firstly, ursodesoxycholic acid and a phenolic compound are added into a chloralkane organic solvent at the room temperature, the temperature is lowered to 10-20 DEG C, a condensing agent is added, thorough reaction is carried out under the temperature of 5-45 DEG C in a heat preservation mode after dripping is completed, filter liquor is concentrated after filtering to obtain a crude product, and the crude product is recrystallized to obtain a ursodesoxycholic acid phenolic ester refined product; secondly, taurine salt and a crown ether complexing agent are added into water to be dissolved, a taurine salt crown ether complex is obtained after concentration, the ursodesoxycholic acid phenolic ester refined product and the taurine salt crown ether complex are added into an organic solvent to be reacted, acid is added after thorough reaction and stirred, solids are separated out and filtered, a filter cake is dissolved in water, stirred and subjected to crystallization, and tauro ursodesoxy cholic acid is obtained. The synthetic method is low in cost, operation is simple and controllable, the product is high in yield and purity, meanwhile, the isomer impurity taurochenodeoxycholic acid of tauro ursodesoxy cholic acid can be well controlled, and the preparing method is suitable for industrial production.
