916243-37-3

Upstream product

• 833485-11-3 methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Downstream Products

• 1354633-53-6 C₂₀H₂₂O₄ 
• 1354633-50-3 C₂₀H₂₀O₄ 
• 916243-39-5 (Z)-methyl 2-[11-(3-hydroxypropylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl]acetate 
• 140462-76-6 olopatadine hydrochloride 
• 916243-38-4 methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate 
• 113806-05-6 olopatadine 

Relevant academic research and scientific papers

Novel and Efficient Synthesis of Deuterium-Labeled Olopatadine-d6

A novel and highly efficient synthetic approach has been developed for the synthesis of deuterium-labeled olopatadine-d6 using inexpensive and commercially available dimethyl sulfate-d6 at the stage of alkylation of primary amine intermediate. The proposed synthetic path makes it possible to avoid the use of expensive labeled reagents such as dimethyl amine-d6 used as labeled precursor in the traditional synthetic route. The structure of the obtained olapatadine-d6 has been confirmed by 1H NMR and mass spectral data.

A new efficient synthetic route for the synthesis of the antiallergic drug, olopatadine hydrochloride, via stereospecific palladium-catalyzed reaction

A new practical and efficient synthetic route for the synthesis of olopatadine hydrochloride via the intramolecular stereospecific seven-membered ring cyclization from an alkyne intermediate using palladium catalyst and hydride source was established. Furthermore, the optimization of that key stereospecific reaction was examined by design of experiment (DoE), and the desired Z-isomer could be obtained with high yield.