916243-39-5

Upstream product

• 1354633-17-2 C₁₅H₁₈O₅ 
• 1354633-33-2 C₁₅H₁₆O₅ 
• 1354633-20-7 C₁₃H₁₄O₄ 
• 916243-38-4 methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate 
• 833485-11-3 methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate 
• 916243-37-3 methyl 2-{4-[(2-bromobenzyl)oxy]-3-iodophenyl}acetate 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 34918-57-5 methyl 3-bromo-4-hydroxyphenylacetate 
• 100126-08-7 3-Brom-4-methoxymethyloxy-phenylessigsaeure-methylester 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 55689-64-0 methyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetate 

Downstream Products

• 140462-76-6 olopatadine hydrochloride 
• 113806-05-6 olopatadine 

Relevant academic research and scientific papers

A PROCESS FOR THE SYNTHESIS OF OLOPATADINE

The present invention provides a process for the synthesis of olopatadine. Further, the invention discloses a process that results in improved yield of the desired Z isomer.

A simple synthesis of the novel antihistaminic drug olopatadine hydrochloride

A new alternative route for the synthesis of olopatadine is described. The present strategy involves a Lewis acid mediated ring opening of a cyclic ether to introduce 3-(dimethylamino)propylidene group as the side chain. Georg Thieme Verlag Stuttgart . New York.

A new efficient synthetic route for the synthesis of the antiallergic drug, olopatadine hydrochloride, via stereospecific palladium-catalyzed reaction

A new practical and efficient synthetic route for the synthesis of olopatadine hydrochloride via the intramolecular stereospecific seven-membered ring cyclization from an alkyne intermediate using palladium catalyst and hydride source was established. Furthermore, the optimization of that key stereospecific reaction was examined by design of experiment (DoE), and the desired Z-isomer could be obtained with high yield.