1354633-50-3

Upstream product

• 1354633-17-2 C₁₅H₁₈O₅ 
• 1354633-33-2 C₁₅H₁₆O₅ 
• 1354633-20-7 C₁₃H₁₄O₄ 
• 916243-38-4 methyl 2-{4-[(2-bromobenzyl)oxy]-3-(4-hydroxybut-1-yn-1-yl)phenyl}acetate 
• 833485-11-3 methyl 2-{4-[(2-bromobenzyl)oxy]phenyl}acetate 
• 916243-37-3 methyl 2-{4-[(2-bromobenzyl)oxy]-3-iodophenyl}acetate 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 34918-57-5 methyl 3-bromo-4-hydroxyphenylacetate 
• 100126-08-7 3-Brom-4-methoxymethyloxy-phenylessigsaeure-methylester 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 

Relevant academic research and scientific papers

A new efficient synthetic route for the synthesis of the antiallergic drug, olopatadine hydrochloride, via stereospecific palladium-catalyzed reaction

A new practical and efficient synthetic route for the synthesis of olopatadine hydrochloride via the intramolecular stereospecific seven-membered ring cyclization from an alkyne intermediate using palladium catalyst and hydride source was established. Furthermore, the optimization of that key stereospecific reaction was examined by design of experiment (DoE), and the desired Z-isomer could be obtained with high yield.