916518-48-4

Basic information

• Product Name: 2-phenyl-1-(pyridin-2-yl)pyrrolidine
• Synonyms: 2-phenyl-1-(pyridin-2-yl)pyrrolidine
• CAS NO: 916518-48-4
• Molecular Weight: 224.305
• Mol File: 916518-48-4.mol

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1-(pyridin-2-yl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1-(pyridin-2-yl)pyrrolidine(916518-48-4)
• EPA Substance Registry System: 2-phenyl-1-(pyridin-2-yl)pyrrolidine(916518-48-4)

Safety Data

• Hazardous Substances Data: 916518-48-4(Hazardous Substances Data)

Upstream product

• 54660-06-9 2-pyrrolidinopyridine 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 916518-31-5 2-phenyl-1-(3,4-dihydro-2H-pyrrol-5-yl)pyrrolidine 
• 109-04-6 2-bromo-pyridine 
• 1006-64-0 2-(phenyl)pyrrolidine 

Downstream Products

• 916518-59-7 2,6-diphenyl-1-(pyridin-2-yl)pyrrolidine 

Relevant articles and documents

sp3 C-H bond arylation directed by amidine protecting group: α-arylation of pyrrolidines and piperidines

A new ruthenium-catalyzed direct sp3 C-H to C-C bond transformation is disclosed. Specifically, a method for the α-arylation of cyclic amines, containing either permanent (pyridine, pyrimidine) or removable (amidine) directing groups, is descri

C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation

All you need is an open vial! The direct α arylation of cyclic alkylamines (see scheme) requires an open vial, as the hydrogen atom involved in the C(sp3)-H-activation process is ultimately released as hydrogen gas. Reports on the formation of hydrogen gas in direct transition-metal- catalyzed functionalizations are still rare. Open-vial reactions proved crucial to this direct arylation procedure as, upon sealing, catalyst deactivation occurs.