91658-92-3

Usage

Uses

Used in Pharmaceutical Industry:
2-FLUORO-3-HYDROXYBENZOIC ACID is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity contribute to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-FLUORO-3-HYDROXYBENZOIC ACID serves as a key component in the production of pesticides and other agrochemicals. Its incorporation enhances the effectiveness of these products in controlling pests and diseases in agriculture.
Used in Dye Industry:
2-FLUORO-3-HYDROXYBENZOIC ACID is utilized as a starting material for the synthesis of dyes. Its presence in the molecular structure of dyes imparts specific color characteristics and properties, making it suitable for various applications in the dye industry.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-FLUORO-3-HYDROXYBENZOIC ACID is used for the preparation of various organic compounds. Its reactivity allows it to undergo multiple chemical reactions, facilitating the synthesis of complex molecules for research and industrial applications.
Solubility:
2-FLUORO-3-HYDROXYBENZOIC ACID is soluble in organic solvents such as ethanol and acetone, which further enhances its utility in various chemical processes and applications.

InChI:InChI=1/C7H5FO3/c8-6-4(7(10)11)2-1-3-5(6)9/h1-3,9H,(H,10,11)

Upstream product

• 137654-20-7 2-fluoro-3-methoxybenzoic acid 
• 117570-31-7 fluoro-1 methoxymethylenoxy-2 benzene 
• 367-12-4 2-fluorophenol 

Downstream Products

• 1214324-64-7 methyl 2-fluoro-3-hydroxybenzoate 
• 1261621-20-8 C₇H₄ClFO₂ 

Relevant academic research and scientific papers

PYRROLOPYRIMIDINE ITK INHIBITORS FOR TREATING INFLAMMATION AND CANCER

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structure of Formula (I): wherein R1, R2, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

PYRROLOTRIAZINE KINASE INHIBITORS

The present invention provides compounds of formula I, (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as ant

Fluorophenols and (trifluoromethyl)phenols as substrates of site-selective metalation reactions: To protect or not to protect

O-Methoxymethyl (MOM) protected fluorophenols can be cleanly metalated and subsequently be submitted to site-selective electrophilic substitution. The 2- and 4-isomers exhibit ambivalent reactivity: deprotonation occurs at the position adjacent to the oxygen when butyllithium is employed whereas the position adjacent to the fluorine is attacked by the superbasic mixture of butyllithium and potassium tert-butoxide (LIC-KOR). The MOM-protected (trifluoromethyl)-phenols react exclusively at oxygen-neighboring positions. The meta isomer provides another example of optional site selectivity, undergoing hydrogen/metal exchange at the 2-position with the LIC-KOR reagent and at the 6-position with sec-butyllithium. Unprotected (trifluoromethyl)phenols can also be ortho-metalated after O-deprotonation, although the products are formed in only moderate yields.