916598-60-2Relevant articles and documents
Hydrazone- and hydrazide-containing N-substituted glycines as peptoid surrogates for expedited library synthesis: Application to the preparation of Tsg101-directed HIV-1 budding antagonists
Liu, Fa,Stephen, Andrew G.,Adamson, Catherine S.,Gousset, Karine,Aman, M. Javad,Freed, Eric O.,Fisher, Robert J.,Burke Jr., Terrence R.
, p. 5165 - 5168 (2007/10/03)
(Chemical Equation Presented) Replacing the Pro6 in the p6 Gag-derived 9-mer "P-E-P-T-A-P-P-E-E" with N-substituted glycine (NSG) residues is problematic. However, incorporation of hydrazone amides ("peptoid hydrazones") can be readily achieved in library fashion. Furthermore, reduction of these hydrazones to N-substituted "peptoid hydrazides" affords a facile route to library diversification. This approach is demonstrated by application to Tsg101-binding compounds designed as potential HIV budding antagonists.