916656-65-0Relevant academic research and scientific papers
Laccase-mediated deprotection of para-methoxyphenyl (PMP)-protected amines
Verkade, Jorge M. M.,Van Hemert, Lieke J. C.,Quaedflieg, Peter J. L. M.,Schoemaker, Hans E.,Schuermann, Martin,Van Delft, Floris L.,Rutjes, Floris P. J. T.
, p. 1332 - 1336 (2007)
A novel enzymatic procedure for the oxidative deprotection of p-methoxyphenyl (PMP)protected amines is described. By using laceases (E.C. 1.10.3.2) under mildly acidic conditions, a variety of PMP-protected amines were successfully deprotected. The rate of deprotection was solvent-and pH-dependent, and the reaction scope could be increased by using so-called mediators
