(2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol

Base Information

• Chemical Name: (2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol
• CAS No.: 916656-65-0
• Molecular Formula: C₁₈H₂₂N₂O₄
• Molecular Weight: 330.384
• Mol file: 916656-65-0.mol

Synonyms:(2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol

Chemical Property of (2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol

There total 1 articles about (2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol (605683-33-8) + methyl iodide (74-88-4) → (2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol (916656-65-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 40 ℃; for 16h;

DOI:10.1002/adsc.200700060

Reference yield: 77.0%

(2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol (916656-65-0) → (2S,3S)-2-methyl-3-(methylamino)-3-(4-nitrophenyl)propan-1-ol hydrochloride

Guidance literature:

(2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol; With trichloroisocyanuric acid; sulfuric acid; water; In acetonitrile; at 90 ℃; for 0.5h;

With potassium hydroxide; In water; at 20 ℃; pH=11;

With hydrogenchloride; In ethyl acetate; Product distribution / selectivity;

Reference yield:

(2S,3S)-3-((4-methoxyphenyl)(methyl)amino)-2-methyl-3-(4-nitrophenyl)propan-1-ol (916656-65-0) → (2S,3S)-2-methyl-3-(methylamino)-3-(4-nitrophenyl)propan-1-ol

Guidance literature:

With phosphate buffer; In tetrahydrofuran; at 20 ℃; pH=3;

DOI:10.1002/adsc.200700060

upstream raw materials:

(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

methyl iodide