91668-83-6

Basic information

• Product Name: 2-Chloro-3-methylpyridine 1-oxide
• Synonyms: 2-Chloro-3-methylpyridine 1-oxide;2-Chloro-3-Methylpyridine N-o×ide
• CAS NO: 91668-83-6
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57094
• Mol File: 91668-83-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 316.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.22±0.1 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: -0.52±0.10(Predicted)
• CAS DataBase Reference: 2-Chloro-3-methylpyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-methylpyridine 1-oxide(91668-83-6)
• EPA Substance Registry System: 2-Chloro-3-methylpyridine 1-oxide(91668-83-6)

Safety Data

• Hazardous Substances Data: 91668-83-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-methylpyridine 1-oxide is a chemical compound with the molecular formula C6H6ClNO. It is a derivative of pyridine and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is a pale yellow liquid with a slightly pungent odor. It is primarily used as a building block in the production of various chemicals, including pesticides and pharmaceuticals. It is also utilized in the manufacturing of dye intermediates, rubber chemicals, and other organic synthesis processes. Additionally, it is considered to be a potential mutagen and may have harmful effects on aquatic organisms. Overall, 2-Chloro-3-methylpyridine 1-oxide is an important chemical in the production of various industrial and pharmaceutical products, but its potential toxicity should be carefully considered in handling and usage.

Upstream product

• 7463-30-1 N-(2-pyridyl-3-methyl)acetamide 
• 53669-61-7 2-amino-3-methylpyridine 1-oxide 
• 100047-38-9 3-methyl-2-nitro-pyridine-1-oxide 
• 75-36-5 acetyl chloride 
• 18368-76-8 2 chloro-3-methylpyridine 

Downstream Products

• 60323-95-7 2-chloro-3-methyl-4-nitropyridine N-oxide 
• 442129-37-5 6-amino-2-chloro-3-methylpyridine 
• 202217-19-4 6-chloro-5-methyl-3-nitropyridin-2-amine 
• 936727-05-8 Lumacaftor 
• 58596-88-6 2,6-dichloro-3-methyl-5-nitropyridine 
• 58584-94-4 2,6-dichloro-3-methylpyridine 
• 132097-09-7 2,4-dichloro-3-methylpyridine 

Relevant articles and documents

A Journey through Hemetsberger–Knittel, Leimgruber–Batcho and Bartoli Reactions: Access to Several Hydroxy 5- and 6-Azaindoles

The preparation of various 5- and 6-azaindoles, heterocyclic structures that are frequently part of molecules in clinical development, and their monohydroxy analogues were described. Different strategies, relying on the de novo pyrrole ring formation, were investigated and, thanks to Hemetsberger–Knittel, Bartoli and Leimgruber–Batcho approaches, 4- and 7-monohydroxy 5- and 6-azaindoles were obtained. The crucial introduction of the oxygen atom was carried out from halogen derivatives, using nucleophilic substitution reactions under basic conditions with or without a copper catalyst. Some preliminary oxidation reactions have shown that it was yet not possible to synthesize the azaquinone indole structure from monohydroxy azaindole, using molecular oxygen in the presence of salcomine as a catalyst.

Technological method for preparing 2- amino -6-5-methyl-substituted-pyridine (by machine translation)

The reaction solvent of 2 - the method is reacted in a reaction solvent under the action, of 2 - an, acid anhydride and an acid,binding, agent and an amination reagent under the action. of an acid anhydride and 2 - an acid-binding agent and, an amination reagent, 2 -4 - 93/7, 99.8%, 70%. (by machine translation)

SUBSTITUTED AMIDE COMPOUNDS

The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.