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Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-methylpyridine 1-oxide is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with potential therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-3-methylpyridine 1-oxide is utilized as a building block in the production of pesticides, playing a crucial role in the development of effective and targeted pest control agents.
Used in Dye Intermediates Production:
2-Chloro-3-methylpyridine 1-oxide is also used as an intermediate in the manufacturing of dye intermediates, which are essential for the production of various dyes used in different industries, including textiles and plastics.
Used in Rubber Chemicals Industry:
2-Chloro-3-methylpyridine 1-oxide finds application in the rubber chemicals industry, where it is employed in the synthesis of additives and other chemicals that enhance the properties of rubber products.

Upstream product

• 7463-30-1 N-(2-pyridyl-3-methyl)acetamide 
• 53669-61-7 2-amino-3-methylpyridine 1-oxide 
• 100047-38-9 3-methyl-2-nitro-pyridine-1-oxide 
• 75-36-5 acetyl chloride 
• 18368-76-8 2 chloro-3-methylpyridine 

Downstream Products

• 442129-37-5 6-amino-2-chloro-3-methylpyridine 
• 60323-95-7 2-chloro-3-methyl-4-nitropyridine N-oxide 
• 202217-19-4 6-chloro-5-methyl-3-nitropyridin-2-amine 
• 936727-05-8 Lumacaftor 
• 58596-88-6 2,6-dichloro-3-methyl-5-nitropyridine 
• 58584-94-4 2,6-dichloro-3-methylpyridine 
• 132097-09-7 2,4-dichloro-3-methylpyridine 

Relevant academic research and scientific papers

A Journey through Hemetsberger–Knittel, Leimgruber–Batcho and Bartoli Reactions: Access to Several Hydroxy 5- and 6-Azaindoles

The preparation of various 5- and 6-azaindoles, heterocyclic structures that are frequently part of molecules in clinical development, and their monohydroxy analogues were described. Different strategies, relying on the de novo pyrrole ring formation, were investigated and, thanks to Hemetsberger–Knittel, Bartoli and Leimgruber–Batcho approaches, 4- and 7-monohydroxy 5- and 6-azaindoles were obtained. The crucial introduction of the oxygen atom was carried out from halogen derivatives, using nucleophilic substitution reactions under basic conditions with or without a copper catalyst. Some preliminary oxidation reactions have shown that it was yet not possible to synthesize the azaquinone indole structure from monohydroxy azaindole, using molecular oxygen in the presence of salcomine as a catalyst.

Method for catalyzing vitamin A isomerization with ruthenium catalyst

The invention provides a method for catalyzing vitamin A isomer conversion with a ruthenium catalyst. According to the method, a ruthenium compound is used as a catalyst, various vitamin A cis-isomerswith low biological activity can be converted into all-trans-isomers with high biological activity in a high proportion in the presence of an auxiliary agent, and the cis-isomers comprise 9-cis-isomers, 11-cis-isomers and 13-cis-isomers. The method has the characteristics of cheap and easily available catalyst, less catalyst dosage, mild reaction conditions, low reaction cost, high isomerizationefficiency and the like.

Technological method for preparing 2- amino -6-5-methyl-substituted-pyridine (by machine translation)

The reaction solvent of 2 - the method is reacted in a reaction solvent under the action, of 2 - an, acid anhydride and an acid,binding, agent and an amination reagent under the action. of an acid anhydride and 2 - an acid-binding agent and, an amination reagent, 2 -4 - 93/7, 99.8%, 70%. (by machine translation)

PROCESS FOR PREPARATION OF LUMACAFTOR

The present invention relates to a process for the preparation of amorphous lumacaftor. The present invention relates to a process for the preparation of intermediate 6-amino-2- halo-3-methylpyridine compounds used in the preparation of lumacaftor. The present invention relates to lumacaftor hydrobromide, process for its preparation and conversion thereof to lumacaftor.

SUBSTITUTED AMIDE COMPOUNDS

The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.

Effects of the pyridine 3-substituent on regioselectivity in the nucleophilic aromatic substitution reaction of 3-substituted 2,6-dichloropyridines with 1-methylpiperazine studied by a chemical design strategy

A chemical design strategy has been used to select 3-substituted 2,6-dichloropyridines for the nucleophilic aromatic substitution reaction with 1-methylpiperazine. The aim was to study the dependency of the regioselectivity in these reactions on the character of the pyridine 3-substituent expressed by their lipophilicity (PI), size (MR), and inductive effect (Ip). Interestingly, the regioselectivity did not correlate with any of these parameters, but in a statistically significant manner with the Verloop steric parameter B1, as indicated by the p value of 0.006 (R2 = 0.45). This implies that bulky 3-substituents close to the pyridine ring induce regioselectivity towards the 6-position. Useful in practical synthesis is the different regioselectivity obtained with a carboxylic acid 3-substituent and precursors or derivatives thereof. Thus, in acetonitrile as solvent, 3-carboxylate and 3-amide substituents were preferred to obtain the 2-isomer (9:1 ratio of the 6-isomer), whereas the 3-cyano and 3-trifluoromethyl substitutents were preferred to obtain the 6-isomer (9:1 ratio of the 2-isomer). Analysis of the regioselectivity Rsel for the pyridine 2-position in the reaction of 2,6-dichloro-3-(methoxycarbonyl)pyridine with 1-methylpiperazine in 21 different solvents showed that Rsel could be predicted by the Kamlet-Taft equation: Rsel = 1.28990 + 0.03992α - 0.59417β - 0.46169π* (R2 = 0.95, p = 1.9 × 10-10). Rsel is thus mainly correlated with the ability of the solvent to function as a hydrogen-bond acceptor, as expressed by the solvatochromic β parameter. Thus, the 16:1 regioselectivity for the 2-isomer in DCM (β = 0.10) could be switched to a 2:1 selectivity for the 6-isomer in DMSO (β = 0.76). Copyright

Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor

(Chemical Equation Presented) Try and fit in: A strategy for the rational design of α5β1 ligands for the purpose of lead generation and biochemical studies on integrin selectivity is based α5β1 homology modeling. Ligand 1 can bind α5β1 with activities in

IMIDAZOPYRIDINE COMPOUND

A compound represented by the following general formula (1), or a salt or hydrate thereof: wherein R1 represents a C1-C6 alkyl group or C2-C6 alkynyl group which may be substituted, or a phenyl group which may be substituted, R2 represents a hydrogen atom or a C1-C6 alkyl group, R3 represents methyl or ethyl group, R4 represents a C1-C6 alkyl group, R5 represents a hydrogen atom, provided that a compound wherein R1 is a C1-C6 alkyl group unsubstituted or substituted with a halogen atom and R2 is a hydrogen atom is excluded.