916830-67-6

Basic information

• Product Name: (S)-4-isopropyl-3-[(S)-4-nitro-3-(2-trifluoromethylphenyl)butyryl]-5,5-diphenyloxazolidin-2-one
• Synonyms: (S)-4-isopropyl-3-[(S)-4-nitro-3-(2-trifluoromethylphenyl)butyryl]-5,5-diphenyloxazolidin-2-one
• CAS NO: 916830-67-6
• Molecular Weight: 540.539
• Mol File: 916830-67-6.mol

Chemical Properties

• CAS DataBase Reference: (S)-4-isopropyl-3-[(S)-4-nitro-3-(2-trifluoromethylphenyl)butyryl]-5,5-diphenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-isopropyl-3-[(S)-4-nitro-3-(2-trifluoromethylphenyl)butyryl]-5,5-diphenyloxazolidin-2-one(916830-67-6)
• EPA Substance Registry System: (S)-4-isopropyl-3-[(S)-4-nitro-3-(2-trifluoromethylphenyl)butyryl]-5,5-diphenyloxazolidin-2-one(916830-67-6)

Safety Data

• Hazardous Substances Data: 916830-67-6(Hazardous Substances Data)

Upstream product

• 218800-33-0 (S)-3-acetyl-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 75-52-5 nitromethane 
• 1032199-08-8 (S)-4-isopropyl-5,5-diphenyl-3-[(E)-3-(2-trifluoromethylphenyl)-acryloyl]-oxazolidin-2-one 

Downstream Products

• 1032199-09-9 methyl (S)-4-nitro-3-(2-trifluoromethylphenyl)butyrate 
• 184346-45-0 (S)-5,5-Diphenyl-4-isopropyl-1,3-oxazolidin-2-one 
• 916830-69-8 (S)-4-(2-trifluoromethylphenyl)pyrrolidin-2-one 

Relevant articles and documents

METHOD FOR PRODUCING PYRROLIDINE COMPOUND

Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. A method of producing a compound represented by the following formula [8]: or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: or a reactive derivative thereof, or a salt thereof, or a solvate thereof.

Heterocyclic compounds

The present invention provides a compound represented by the following formula [1′] or a salt thereof: wherein ring A, R2, R3, R4 and X are as defined in the description, and an agent for the treatment or prophylaxis of a