184346-45-0

Basic information

• Product Name: (S)-(-)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE
• Synonyms: (S)-(-)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE;5,5-DIPHENYL-4-ISOPROPYLOXAZOLIDINE-2-ONE;(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one;(R)-4-Isopropyl-5,5-diphenyloxazolidin-2-one;(S)-(-)-4-Isopropyl-5,5-diphenyl-2-oxazolidinone, ee: 99%;(S)-4-Isopropyl-5,5-diphenyl-2-oxazolidinone,99%e.e.;(S)-(-)-4-Isopropyl-5,5-diphenyl-2-oxazolidinone, 98%, ee: 99%;(4S)-5,5-diphenyl-4-propan-2-yl-1,3-oxazolidin-2-one
• CAS NO: 184346-45-0
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.35
• Product Categories: Intermediates of Sertraline;Asymmetric Synthesis;Chiral Auxiliaries;Oxazolidinone Derivatives
• Mol File: 184346-45-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 252-255 °C(lit.)
• Boiling Point: 475.684 °C at 760 mmHg
• Flash Point: 241.486 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 11.74±0.60(Predicted)
• CAS DataBase Reference: (S)-(-)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE(184346-45-0)
• EPA Substance Registry System: (S)-(-)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE(184346-45-0)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 184346-45-0(Hazardous Substances Data)

Usage

Chemical Properties

White or off-white crystal to power solid

InChI:InChI=1/C18H19NO2/c1-13(2)16-18(21-17(20)19-16,14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-13,16H,1-2H3,(H,19,20)/t16-/m0/s1

Upstream product

• 13734-41-3 t-Boc-L-valine 
• 108-86-1 bromobenzene 
• 58561-04-9 N-tert-butoxycarbonyl-L-valine methyl ester 
• 67-56-1 methanol 
• 916830-67-6 (S)-4-isopropyl-3-[(S)-4-nitro-3-(2-trifluoromethylphenyl)butyryl]-5,5-diphenyloxazolidin-2-one 
• 124-41-4 sodium methylate 
• 282550-81-6 (S)-3-((1S,2S)-2-benzyloxy-3-methyl-1-methylsulfanyl-but-3-enyl)-4-isopropyl-5,5-diphenyl-oxazolidin-2-one 
• 282550-82-7 (S)-3-[(1S,2S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-1-methylsulfanyl-butyl]-4-isopropyl-5,5-diphenyl-oxazolidin-2-one 
• 282550-80-5 (S)-4-isopropyl-3-((1S,2S)-2-methoxymethoxy-1-methylsulfanyl-2-phenyl-ethyl)-5,5-diphenyl-oxazolidin-2-one 
• 282550-79-2 (S)-3-((1S,2S)-2-hydroxy-3-methyl-1-methylsulfanyl-butyl)-4-isopropyl-5,5-diphenyl-oxazolidin-2-one 
• 6306-52-1 L-valine methylester hydrochloride 
• 72-18-4 L-valine 
• 449143-67-3 (S)-3-[(1S,2R,4S)-4-hydroxy-1-(methylsulfanyl)-2,4-diphenylbutyl]-4-isopropyl-5,5-diphenyloxazolidin-2-one 
• 345904-93-0 (S)-4-isopropyl-3-((1S,2R)-2-methyl-1-methylsulfanyl-4-oxo-2,4-diphenyl-butyl)-5,5-diphenyl-oxazolidin-2-one 

Downstream Products

• 944472-89-3 (4S)-3-(2-bromopropanoyl)-4-isopropyl-5,5-diphenyl-1,3-oxazolidin-2-one 
• 464201-35-2 (S)-4-(1-methylethyl)-5,5-diphenyl-3-(prop-2-enyl)oxazolidin-2-one 
• 464201-37-4 (S)-4-(1-methylethyl)-5,5-diphenyl-3-[3-(trimethylsilyl)prop-2-ynyl]oxazolidin-2-one 
• 282550-72-5 (S)-4-isopropyl-3-methylsulfanylmethyl-5,5-diphenyl-oxazolidin-2-one 
• 345904-70-3 (S)-4-isopropyl-5,5-diphenyl-3-phenylsulfanylmethyl-oxazolidin-2-one 
• 290352-01-1 (S)-α-fluorodiphenylmethyl isopropylamine 
• 7495-04-7 2-methyl-4,4-diphenyl-3-butanone 
• 233772-37-7 (S)-3-methyl-1,1-diphenylbutan-2-amine 
• 218800-34-1 (S)-4-(1-methylethyl)-3-(3-methyl-1-oxobutyl)-5,5-diphenyloxazolidin-2-one 
• 218800-36-3 (S)-4-(1-methylethyl)-3-<(E)-1-oxo-3-phenylprop-2-enyl>-5,5-diphenyloxazolidin-2-one 
• 218800-39-6 (S)-3-<3-<4-(benzyloxy)phenyl>-1-oxopropyl>-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 218800-37-4 (S)-3-<4-(methoxycarbonyl)-1-oxobutyl>-4-(1-methylethyl)-5,5-diphenyloxazolidin-2-one 
• 218800-88-5 (S)-4-(1-methylethyl)-3-(4-methyl-1-oxopentyl)-5,5-diphenyloxazolidin-2-one 
• 218800-35-2 (S)-4-(1-methylethyl)-3-<(E)-2-oxobut-2-enyl>-5,5-diphenyloxazolidin-2-one 

Relevant articles and documents

Synthesis and application of N-3,5-dinitrobenzoyl and C3 symmetric diastereomeric chiral stationary phases

Three diastereomeric chiral compounds, namely, (R,R)-(+)-2-amino-1,2-diphenylethanol, (1S,2R)-(+)-2-amino-1,2-diphenylethanol, and (1R,2R)-(+)-1,2-diphenylethylenediamine were used as starting materials for preparing three N-3,5-dinitrobenzoyl derivative

Liquid Chromatographic Resolution of Racemic 2-Oxazolidinones and their Analogs on Seven Pirkle-Type Chiral Stationary Phases

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METHOD FOR PRODUCING PYRROLIDINE COMPOUND

Provided is a method capable of efficiently producing a compound having a superior HSD1 inhibitory action and a compound useful as a synthetic intermediate therefor, with superior achievability of asymmetric synthesis (i.e., superior selectivity), superior yield, superior safety and superior industrial workability at a low cost. A method of producing a compound represented by the following formula [8]: or a salt thereof, or a solvate thereof, from a compound represented by the following formula [2]: or a reactive derivative thereof, or a salt thereof, or a solvate thereof.