916978-92-2Relevant academic research and scientific papers
METHOD FOR MAKING BIARYL COMPOUNDS, COMPOUNDS MADE BY THE METHOD, AND METHOD FOR THEIR USE
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, (2009/01/23)
Certain disclosed embodiments of the present invention concern a method for making biaryl compounds by combining a diene with a dienophile under reaction conditions that facilitate a Diels-Alder reaction. Certain embodiments are particularly directed to making a tetra-ortho-substituted biaryl compounds. The disclosed method may involve using novel dienes, dienophiles, or both. Similarly, certain of the biaryl compounds are novel compounds too. Additional disclosed embodiments concern a method for making useful compounds by first making a Diels-Alder adduct. The Diels-Alder adduct is then further modified or coupled to other compounds. The method can be used to make carbazoles, such as Siamenol. Disclosed biaryl compounds are useful for a number of applications, such as pharmacophores and organocatalysts.
Synthesis of tetra-ortho-substituted, phosphorus-containing and carbonyl-containing biaryls utilizing a Diels-Alder approach
Ashburn, Bradley O.,Carter, Rich G.,Zakharov, Lev N.
, p. 9109 - 9116 (2008/02/09)
The application of the Diels-Alder approach to biaryls (DAB) is described for the synthesis of tetra-ortho-substituted biaryl compounds containing orthogonally functionalized substituents. The syntheses of phosphorus- containing, disubstituted alkynes and
Diels-Alder approach to polysubstituted biaryls: Rapid entry to tri- and tetra-ortho-substituted phosphorus-containing biaryls
Ashburn, Bradley O.,Carter, Rich G.
, p. 6737 - 6741 (2007/10/03)
Rapid construction: A Diels-Alder-based approach to the synthesis of highly functionalized biaryls from readily available precursors is disclosed. The utility of these biaryl templates in palladium-mediated couplings is explored along with subsequent redu
