917077-70-4Relevant articles and documents
Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands
Zhao, Xue Zhi,Semenova, Elena A.,Liao, Chenzhong,Nicklaus, Marc,Pommier, Yves,Burke Jr., Terrence R.
, p. 7816 - 7825 (2006)
The diketo acid (DKA) class of HIV-1 integrase inhibitors are thought to function by chelating divalent metal ions within the enzyme catalytic center. However, differences in mutations conferring resistance among sub-families of DKA inhibitors suggest tha