91713-63-2Relevant academic research and scientific papers
An improved procedure for the regiospecific synthesis of electron deficient 4- and 6-substituted isatins
Kraynack, Erica A.,Dalgard, Jackline E.,Gaeta, Federico C. A.
, p. 7679 - 7682 (2007/10/03)
The regiospecific synthesis of 4- and 6-substituted isatins 5a-g in four steps from halonitrobenzenes 1a-g has been investigated for a variety of substrates (Scheme 1). The procedure makes use of readily available, easily handled materials and in most cases purification of neither intermediates nor final products is required. Yields of isatins are between 26 and 75% (Table 1). Improved yields of known isatins are reported as well as the syntheses of previously unreported isatins. This method, taken together with known procedures, provides for the synthesis of the full complement of isatin regioisomers.
Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues
Walsh,Moran,Shamblee,Uwaydah,Welstead Jr.,Sancilio,Dannenburg
, p. 1379 - 1388 (2007/10/02)
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 4'-chloro, 4'-bromo and 5-chloro, 4'-bromo were more potent than indomethacin in these assays.
