91714-41-9

Usage

Uses

Used in Pharmaceutical Industry:
(4-Bromophenyl)(indolin-7-yl)methanone is used as a reactant in the preparation of 2-amino-3-benzoylphenylacetic acid and analogs, which are important intermediates in the synthesis of pharmaceutical compounds. These intermediates can be further modified or used to produce drugs with potential therapeutic applications, such as anti-inflammatory, analgesic, or antipyretic agents.
Used in Chemical Research:
In the field of chemical research, (4-bromophenyl)(indolin-7-yl)methanone serves as a versatile building block for the development of new organic compounds with potential applications in various industries. Its unique structure allows for the exploration of novel chemical reactions and the synthesis of new molecules with desired properties.
Used in Material Science:
(4-Bromophenyl)(indolin-7-yl)methanone can also be utilized in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity. Its incorporation into polymers, coatings, or other materials can lead to the creation of innovative products with enhanced performance characteristics.

Upstream product

• 496-15-1 1-indoline 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 91714-50-0 7-(4-bromobenzoyl)-1-hydro-indole 
• 91714-43-1 (4-Bromo-phenyl)-(5-chloro-2,3-dihydro-1H-indol-7-yl)-methanone 
• 91714-47-5 (5-bromo-2,3-dihydro-1H-indol-7-yl)(4-bromophenyl)methanone 
• 91715-33-2 Sodium; [2-amino-3-(4-bromo-benzoyl)-5-chloro-phenyl]-acetate 
• 91715-43-4 Sodium; [2-amino-5-bromo-3-(4-bromo-benzoyl)-phenyl]-acetate 
• 91714-38-4 5-Bromo-7-(4-bromo-benzoyl)-1,3-dihydro-indol-2-one 
• 91714-34-0 7-(4-bromobenzoyl)-5-chloro-1,3-dihydro-2H-indol-2-one 
• 91714-67-9 (4-Bromo-phenyl)-(3,5-dibromo-1H-indol-7-yl)-methanone 
• 91714-59-9 (3-bromo-5-chloro-1H-indol-7-yl)(4-bromophenyl)-methanone 
• 91714-51-1 (4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone 
• 91714-66-8 (5-Bromo-1H-indol-7-yl)-(4-bromo-phenyl)-methanone 
• 91714-58-8 (4-bromophenyl)(5-chloro-1H-indol-7-yl)methanone 
• 405275-36-7 (4-bromo-phenyl)-(1-ethyl-1H-indol-7-yl)-methanone 

Relevant academic research and scientific papers

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.

Preparation and pharmacological profile of 7-(α-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors

Aromatase (P450 arom) is a target of pharmacological interest for the treatment of breast cancer. New series of 7-(α-azolylbenzyl)-1H-indoles and indolines were synthesized as non-steroidal inhibitors of P450 arom. Selectivity was studied towards P450 17α enzyme. The most active compound, 1-ethyl-7-[(imidazol-1-yl)(4-chlorophenyl)methyl]-1H-indole 12c exhibited promising relative potency (rp) of 336 (rp of aminoglutethimide=1) and most of the described azoles were active and selective towards P450 arom.

Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues

A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 4'-chloro, 4'-bromo and 5-chloro, 4'-bromo were more potent than indomethacin in these assays.