91714-50-0

Basic information

• Product Name: 7-(4-Bromobenzoyl)indole
• Synonyms: 7-(4-Bromobenzoyl)indole
• CAS NO: 91714-50-0
• Molecular Formula: C₁₅H₁₀BrNO
• Molecular Weight: 300.154
• EINECS: -0
• Mol File: 91714-50-0.mol

Chemical Properties

• Melting Point: 162-164℃
• Boiling Point: 468.6±20.0 °C(Predicted)
• Appearance: /
• Density: 1.530
• PKA: 15.06±0.30(Predicted)
• CAS DataBase Reference: 7-(4-Bromobenzoyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-Bromobenzoyl)indole(91714-50-0)
• EPA Substance Registry System: 7-(4-Bromobenzoyl)indole(91714-50-0)

Safety Data

• Hazardous Substances Data: 91714-50-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
7-(4-Bromobenzoyl)indole is used as a starting material for the synthesis of other pharmaceutical compounds due to its unique chemical structure and reactivity.
Used in Pharmaceutical Research:
7-(4-Bromobenzoyl)indole is used as a research tool for studying the mechanisms of action of certain drugs, providing insights into the development of new therapeutic agents.
Used in Medicinal Chemistry:
7-(4-Bromobenzoyl)indole is used as a potential therapeutic agent for the treatment of various diseases and conditions, given its ability to modulate various biological pathways and targets. Further research is needed to fully understand its pharmacological properties and potential uses.
Used in Drug Discovery:
7-(4-Bromobenzoyl)indole is employed in drug discovery processes to identify new lead compounds and optimize their properties for specific therapeutic applications. Its unique structure and functional groups make it a valuable candidate for the development of novel pharmaceuticals.

Upstream product

• 91714-41-9 (4-bromophenyl)(2,3-dihydro-1H-indol-7-yl)methanone 
• 496-15-1 1-indoline 
• 623-00-7 4-bromobenzenecarbonitrile 

Downstream Products

• 91714-93-1 bromfenac sodium 
• 91714-94-2 bromfenac 
• 91713-91-6 7-(4-bromobenzoyl)-1,3-dihydro-2H-indol-2-one 
• 405275-36-7 (4-bromo-phenyl)-(1-ethyl-1H-indol-7-yl)-methanone 
• 91714-51-1 (4-Bromo-phenyl)-(3-chloro-1H-indol-7-yl)-methanone 

Relevant articles and documents

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.

Preparation and pharmacological profile of 7-(α-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors

Aromatase (P450 arom) is a target of pharmacological interest for the treatment of breast cancer. New series of 7-(α-azolylbenzyl)-1H-indoles and indolines were synthesized as non-steroidal inhibitors of P450 arom. Selectivity was studied towards P450 17α enzyme. The most active compound, 1-ethyl-7-[(imidazol-1-yl)(4-chlorophenyl)methyl]-1H-indole 12c exhibited promising relative potency (rp) of 336 (rp of aminoglutethimide=1) and most of the described azoles were active and selective towards P450 arom.

Process for the production of 7-acylindoles

A process for the production of 7-acylindoles of the general formula: STR1 starting from indoline of the formula: STR2 Indoline is cyanized in a first stage to 7-cyanoindoline of the formula: STR3 The latter is catalytically dehydrogenated in a second stage to 7-cyanindole of the formula: STR4 The latter is then acylated in a third stage with an organometallic compound of the formula: into the end product according to formula I.

Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues

A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 4'-chloro, 4'-bromo and 5-chloro, 4'-bromo were more potent than indomethacin in these assays.