917363-80-5

Basic information

• Product Name: 5-chloro-3-phenyl-2-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-[1,6]naphthyridine
• Synonyms: 5-chloro-3-phenyl-2-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-[1,6]naphthyridine
• CAS NO: 917363-80-5
• Molecular Weight: 558.085
• Mol File: 917363-80-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-phenyl-2-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-[1,6]naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-phenyl-2-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-[1,6]naphthyridine(917363-80-5)
• EPA Substance Registry System: 5-chloro-3-phenyl-2-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-[1,6]naphthyridine(917363-80-5)

Safety Data

• Hazardous Substances Data: 917363-80-5(Hazardous Substances Data)

Upstream product

• 187834-88-4 tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate 
• 105-07-7 4-cyanobenzaldehyde 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 66739-89-7 4-(1,3-dioxolan-2-yl)benzonitrile 
• 868280-61-9 1-[4-(1,3-dioxolan-2-yl)phenyl]-2-phenylethanone 
• 917363-82-7 5-chloro-2-(4-[1,3]dioxolan-2-yl-phenyl)-3-phenyl-[1,6]naphthyridine 
• 893423-62-6 tert-butyl (2-chloro-3-formylpyridin-4-yl)carbamate 
• 868280-57-3 tert-butyl 4-[5-(pyridin-2-yl)-1H-1,2,4-triazol-3-yl]piperidine-1-carboxylate 
• 14432-12-3 4-Amino-2-chloropyridine 
• 100-70-9 2-Cyanopyridine 
• 234108-73-7 (2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester 
• 893422-47-4 C₃₃H₂₉N₇O 
• 893422-47-4 3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridin-5(6H)-one 
• 917363-90-7 4-(5-chloro-3-phenyl-[1,6]naphthyridin-2-yl)-benzaldehyde 

Downstream Products

• 917359-62-7 9-phenyl-8-(4-{[4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)[1,2,4]triazolo[3,4-f]-1,6-naphthyridine 
• 917363-81-6 5-hydrazino-3-phenyl-2-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine 
• 917363-81-6 (3-phenyl-2-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-[1,6]naphthyridin-5-yl)-hydrazine 

Relevant articles and documents

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

A series of [1,2,4]triazolo[3,4-f][1,6]naphthyridine allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been shown to have potent dual Akt1 and 2 cell potency. The representative compound 13 provided potent inhibitory activity against Akt1 and 2 in vivo in a mouse model.

INHIBITORS OF AKT ACTIVITY

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.