917483-13-7Relevant articles and documents
Synthesis of enantiomerically pure d- and l-bicyclo[3.1.0]hexenyl carbanucleosides and their antiviral evaluation
Park, Ah-Young,Kim, Won Hee,Kang, Jin-Ah,Lee, Hye Jin,Lee, Chong-Kyo,Moon, Hyung Ryong
, p. 3945 - 3955 (2011)
Based upon the fact that l-nucleosides have been generally known to be less cytotoxic than d-counterparts, l-bicyclo[3.1.0]hexenyl carbanucleoside derivatives with a fixed north conformation were designed and synthesized by employing a novel synthetic str
Asymmetric synthesis and biological activity of l-bicyclocarba-d4T
Moon, Hyung Ryong,Park, Ah-Young,Kim, Kyung Ran,Chun, Moon Woo,Jeong, Lak Shin
, p. 1653 - 1657 (2008/09/18)
Novel l-bicyclocarba-d4T (1), an enantiomer of d-N-MCd4T has been enantiopurely synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group
Asymmetric synthesis of novel pseudo-D-vinylcyclopropyl nucleosides bearing quaternary carbon as potential anti-herpesvirus agent
Park, Ah-Young,Moon, Hyung Ryong,Kim, Kyung Ran,Chun, Moon Woo,Jeong, Lak Shin
, p. 1001 - 1004 (2008/03/28)
Pseudo-d-vinylcyclopropyl nucleosides 10-12 bearing a quaternary carbon were designed and synthesized starting from (R)-epichlorohydrin using a tandem reaction of double alkylation and lactonization via oxirane-ring opening reaction, a Wittig reaction, an
Synthesis of novel l-N-MCd4T as a potent anti-HIV agent
Park, Ah-Young,Moon, Hyung Ryong,Kim, Kyung Ran,Chun, Moon Woo,Jeong, Lak Shin
, p. 4065 - 4067 (2008/09/19)
l-N-MCd4T (1) has been synthesized as a potent anti-HIV agent starting from (R)-epichlorohydrin using tandem alkylation, chemoselective reduction of ester in the presence of lactone functional group, RCM reaction and Mitsunobu reaction as key steps and wa