917903-27-6

Basic information

• Product Name: 1-(2-chloro-phenyl)-2-{2-[3-(3-piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-ethanone
• Synonyms: 1-(2-chloro-phenyl)-2-{2-[3-(3-piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-ethanone
• CAS NO: 917903-27-6
• Molecular Weight: 441.013
• Mol File: 917903-27-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2-chloro-phenyl)-2-{2-[3-(3-piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloro-phenyl)-2-{2-[3-(3-piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-ethanone(917903-27-6)
• EPA Substance Registry System: 1-(2-chloro-phenyl)-2-{2-[3-(3-piperidin-1-yl-propoxy)-phenyl]-pyrrolidin-1-yl}-ethanone(917903-27-6)

Safety Data

• Hazardous Substances Data: 917903-27-6(Hazardous Substances Data)

Upstream product

• 917903-00-5 1-[3-(3-pyrrolidin-2-yl-phenoxy)-propyl]-piperidine 
• 5000-66-8 2-chlorophenacyl bromide 
• 917902-99-9 1-{3-[3-(4,5-dihydro-3H-pyrrol-2-yl)-phenoxy]-propyl}-piperidine 
• 939772-49-3 C₁₇H₂₅NO₃ 
• 939772-48-2 C₁₂H₁₅IO₃ 
• 117022-45-4 3-(3-chloro-propoxy)-benzoic acid ethyl ester 
• 7781-98-8 ethyl-3-hydroxybenzoate 

Relevant articles and documents

Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors

A series of novel and potent pyrrolidino-tetrahydroisoquinolines with dual histamine H3 antagonist/serotonin transporter inhibitor activity is described. A highly regio- and diastereoselective synthesis of the pyrrolidino-tetrahydroisoquinoline core involving acid mediated ring-closure of an acetophenone intermediate followed by reduction with NaCNBH3 was developed. In vitro and in vivo data are discussed.