91806-74-5Relevant academic research and scientific papers
New facile alkoxycarbonylating agent, alkyl pyrazole-1-carboxylates. The preparation and the utilities
Kashima, Choji,Tsuruoka, Shiro,Mizuhara, Saori
, p. 14679 - 14688 (2007/10/03)
Alkyl pyrazole-1-carboxylates (2), which were readily prepared from alkyl chloroformate or carbazate in good yields, were provided as the new facile alkoxycarbonylating agents toward the Grignard reagents for the synthesis of one carbon higher carboxylic esters. Also amines were alkoxycarbonylated by 2 to produce the corresponding urethanes even in an aqueous medium. Benzyl 3,5-dimethylpyrazole-1-carboxylate (2d) could be utilized for the Cbz-protection of amino acids and esters in good yield without any racemization.
