918159-85-0Relevant academic research and scientific papers
Enantioselective synthesis of diversely substituted quaternary 1,4-benzodiazepin-2-ones and 1,4-benzodiazepine-2,5-diones
Carlier, Paul R.,Zhao, Hongwu,MacQuarrie-Hunter, Stephanie L.,DeGuzman, Joseph C.,Hsu, Danny C.
, p. 15215 - 15220 (2007/10/03)
Benzodiazepines are privileged scaffolds in medicinal chemistry, but enantiopure examples containing quaternary stereogenic centers are extremely rare. We demonstrate that installation of the di-(p-anisyl)methyl (DAM) group at N1 of 1,4-benzodiazepin-2-on
