918161-07-6Relevant articles and documents
Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity
Szymanski, Wiktor,Zwolinska, Magdalena,Klossowski, Szymon,M?ynarczuk-Bia?y, Izabela,Bia?y, ?ukasz,Issat, Tadeusz,Malejczyk, Jacek,Ostaszewski, Ryszard
, p. 1773 - 1781 (2014)
The utility of a novel, chemoenzymatic procedure for the stereocontrolled synthesis of small peptides is presented in the preparation and structure optimisation of dipeptides with cytostatic/cytotoxic activity. The method uses Passerini multicomponent rea
Studies on the application of the Passerini reaction and enzymatic procedures to the synthesis of tripeptide mimetics
Szymanski, Wiktor,Zwolinska, Magdalena,Ostaszewski, Ryszard
, p. 7647 - 7653 (2008/02/08)
A new, efficient method for the multicomponent synthesis of tripeptide mimetics is presented. Simple, chemoenzymatic transformations of Passerini reaction products enable the introduction of varied amino acid moieties into the tripeptide scaffold, with co
Multicomponent diversity and enzymatic enantioselectivity as a route towards both enantiomers of α-amino acids-a model study
Szymanski, Wiktor,Ostaszewski, Ryszard
, p. 2667 - 2671 (2007/10/03)
A model study on a new, enantioconvergent method for the synthesis of chiral, nonracemic α-amino acids is presented. α-Acetoxyamides obtained in a Passerini multicomponent reaction are selectively hydrolyzed by Wheat Germ lipase. Studies on conversion of the thus obtained, enantiomerically enriched α-hydroxyamides into α-aminoamides are presented. Products of these reactions are then hydrolyzed to give α-amino acids.
