918161-30-5Relevant academic research and scientific papers
A platform for designing HIV integrase inhibitors. Part 1: 2-Hydroxy-3-heteroaryl acrylic acid derivatives as novel HIV integrase inhibitor and modeling of hydrophilic and hydrophobic pharmacophores
Kawasuji, Takashi,Yoshinaga, Tomokazu,Sato, Akihiko,Yodo, Mitsuaki,Fujiwara, Tamio,Kiyama, Ryuichi
, p. 8430 - 8445 (2008/02/05)
We present a novel series of HIV integrase inhibitors, showing IC50s ranging from 0.01 to over 370 μM in an enzymatic assay. Furthermore, pharmacophore modeling study for the inhibitors was carried out to elucidate the structure-activity relationships. Finally, we found a 3D-pharmacophore model, which is composed of a hydrophilic and a hydrophobic domain, providing valuable information for designing other novel types of integrase inhibitors.
