918165-52-3

Upstream product

• 16619-14-0 2-phenyl-2,3-dihydro-1H-quinolin-4-one 
• 1253935-16-8 1-(2-azido-phenyl)-3-phenyl-propan-1-ol 
• 100-52-7 benzaldehyde 
• 551-93-9 2-aminoacetophenone 
• 78396-00-6 2-aminochalcone 

Downstream Products

• 918165-54-5 C₁₆H₁₇NO 
• 1171952-71-8 2-phenyl-4-imidazol-1-yl-1,2,3,4-tetrahydro-quinoline 
• 1171952-86-5 2-phenyl-4-[1,2,4]triazol-1-yl-1,2,3,4-tetrahydro-quinoline 

Relevant academic research and scientific papers

[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones have been accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation using aryl azides as nitrogen source.

NOVEL TETRAHYDROQUINOLINES AS AROMATASE INHIBITORS

The invention relates to synthesis and biological screening of novel tetrahydroquinolines of formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them for aromatase inhibition: (I).The present invention also relates to a process for the preparation of the novel tetrahydroquinolines, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in for aromatase inhibition, particularly in the treatment and/or prevention of cancer, particularly breast cancer, more particularly hormone dependent breast cancer.

Synthesis and characterization of [1]benzopyrano[4,3-d][1,3]benzooxazocin- 13-one and its derivatives

This work describes the efficient synthesis of functionalized cleft molecules 6, 6a, 16, 16a, 17, 19 and 20 derived from benzopyrano[4,3-d][1,3] benzooxazocin-13-one. X-ray crystal structure analysis of compounds 6a and 16a revealed that the cleft angles of the planes of the benzopyran moiety and the p-methoxybenzene ring are 109.4° and 108.6°, respectively. The conformation of the aromatic ring at the bridgehead of 16, 16a and 20 is restricted by the gem-dimethyl groups on the C-9 position and the methyl group on the nitrogen atom in the ring. Georg Thieme Verlag Stuttgart.