91826-95-8

Basic information

• Product Name: 1H-Indole-3-propanoic acid, 1-[[(methoxycarbonyl)amino]acetyl]-, phenylmethyl ester
• CAS NO: 91826-95-8
• Molecular Formula: C22H22N2O5
• Molecular Weight: 394.427
• Mol File: 91826-95-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Indole-3-propanoic acid, 1-[[(methoxycarbonyl)amino]acetyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-propanoic acid, 1-[[(methoxycarbonyl)amino]acetyl]-, phenylmethyl ester(91826-95-8)
• EPA Substance Registry System: 1H-Indole-3-propanoic acid, 1-[[(methoxycarbonyl)amino]acetyl]-, phenylmethyl ester(91826-95-8)

Safety Data

• Hazardous Substances Data: 91826-95-8(Hazardous Substances Data)

Upstream product

• 1670-94-6 N-methoxycarbonylglycine p-nitrophenyl ester 
• 85612-35-7 benzyl 3-indole propionate 

Relevant articles and documents

Synthesis of the Imidazoindole-spirolactone Ring System by Oxidative Double Cyclization. A Synthetic Approach to Tryptoquivalines

Imidazoindole-spirolactone 13, the principal ring system of tryptoquivalines, was succesfully synthesized by a new method via oxidative double cyclization of 1-(N-alkoxycarbonylalanyl)-3-indolepropionic acids (5) with N-bromosuccinimide, which were synthesized by acylation of benzyl 3-indolepropionate (10) with N-alkoxycarbonyl alanine p-nitrophenyl ester (12).The use of KF, 18-crown-6 and (iso-Pr)2NEt in acetonitrile lead to high yields of benzyl 1-(N-methoxycarbonyl-α-methylalanyl)-3-indolepropionates (4).The removal of the protecting group of 13c provided 2.The mechanisms of these reactions are discussed.Keywords - tryptoquivaline; imidazoindole-spirolactone; 1-(N-alkoxycarbonylalanyl)-3-indolepropionic acid; oxidative double cyclization; N-bromosuccinimide; acylation.