1670-94-6

Basic information

• Product Name: methoxycarbonylglycine 4-nitrophenyl ester
• Synonyms: methoxycarbonylglycine 4-nitrophenyl ester
• CAS NO: 1670-94-6
• Molecular Formula: C₁₀H₁₀N₂O₆
• Molecular Weight: 254.2
• Mol File: 1670-94-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 446.6°Cat760mmHg
• Flash Point: 223.9°C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 3.59E-08mmHg at 25°C
• Refractive Index: 1.551
• PKA: 10.39±0.46(Predicted)
• CAS DataBase Reference: methoxycarbonylglycine 4-nitrophenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: methoxycarbonylglycine 4-nitrophenyl ester(1670-94-6)
• EPA Substance Registry System: methoxycarbonylglycine 4-nitrophenyl ester(1670-94-6)

Safety Data

• Hazardous Substances Data: 1670-94-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10N2O6/c1-17-10(14)11-6-9(13)18-8-4-2-7(3-5-8)12(15)16/h2-5H,6H2,1H3,(H,11,14)

Upstream product

• 100-02-7 4-nitro-phenol 
• 1670-97-9 N-(methoxycarbonyl)glycine 

Downstream Products

• 100-02-7 4-nitro-phenol 
• 91826-95-8 benzyl 1-(N-methoxycarbonylglycyl)-3-indolepropionate 
• 85612-35-7 benzyl 3-indole propionate 

Relevant articles and documents

Synthesis of the Imidazoindole-spirolactone Ring System by Oxidative Double Cyclization. A Synthetic Approach to Tryptoquivalines

Imidazoindole-spirolactone 13, the principal ring system of tryptoquivalines, was succesfully synthesized by a new method via oxidative double cyclization of 1-(N-alkoxycarbonylalanyl)-3-indolepropionic acids (5) with N-bromosuccinimide, which were synthesized by acylation of benzyl 3-indolepropionate (10) with N-alkoxycarbonyl alanine p-nitrophenyl ester (12).The use of KF, 18-crown-6 and (iso-Pr)2NEt in acetonitrile lead to high yields of benzyl 1-(N-methoxycarbonyl-α-methylalanyl)-3-indolepropionates (4).The removal of the protecting group of 13c provided 2.The mechanisms of these reactions are discussed.Keywords - tryptoquivaline; imidazoindole-spirolactone; 1-(N-alkoxycarbonylalanyl)-3-indolepropionic acid; oxidative double cyclization; N-bromosuccinimide; acylation.