918329-97-2

Upstream product

• 186581-53-3 diazomethane 
• 109638-99-5 (+/-)-1-benzyloxycarbonylamino-3-methylbutylphosphonous acid 
• 67-56-1 methanol 
• 121-45-9 phosphorous acid trimethyl ester 
• 501-53-1 benzyl chloroformate 
• 590-86-3 isovaleraldehyde 
• 80744-65-6 1-Amino-3-methyl-butylphosphonous acid 
• 65577-21-1 [1-[(diphenylmethyl)amino]-3-methylbutyl]phosphinic acid 

Downstream Products

• 109639-04-5 C₂₈H₃₉N₂O₇P 
• 109639-03-4 C₂₅H₄₁N₂O₇P 
• 109639-07-8 phenylmethyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate 
• 109639-05-6 C₂₇H₃₇N₂O₇P 
• 109639-02-3 methyl N-<amino>-3-methylbutyl>phosphinyl>carbonyl>-L-leucinate 
• 109639-14-7 C₂₁H₃₃N₂O₇P 
• 109639-10-3 C₂₀H₃₁N₂O₇P 

Relevant academic research and scientific papers

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.

Facile synthesis of bis-α-aminoalkylphosphinates

Herein we report a facile synthesis of esters of bis-α- aminoalkylphosphinic acids obtained by an addition of Cbz-protected phosphinic analogues of amino acid methyl esters to an appropriate imine in refluxing benzene. Complete deprotection of the esters